Literature DB >> 10406655

Synthesis of water-soluble phenytoin prodrugs.

J Bosch1, T Roca, J Domènech, M Suriol.   

Abstract

The synthesis of novel water-soluble phenytoin derivatives, bearing an ionizable group, and a preliminary study for in vitro blood hydrolysis are reported. The results show that hydrolysis of amino esters 8 is very fast, much more than that of fosphenytoin.

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Year:  1999        PMID: 10406655     DOI: 10.1016/s0960-894x(99)00294-2

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  1 in total

Review 1.  The Bucherer-Bergs Multicomponent Synthesis of Hydantoins-Excellence in Simplicity.

Authors:  Martin Kalník; Peter Gabko; Maroš Bella; Miroslav Koóš
Journal:  Molecules       Date:  2021-06-30       Impact factor: 4.411

  1 in total

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