| Literature DB >> 10406654 |
O Parve1, I Järving, I Martin, A Metsala, I Vallikivi, M Aidnik, T Pehk, N Samel.
Abstract
Natural prostaglandins (PG) F2alpha and E1 as well as (+)-cloprostenol were regioselectively 11-acylated using Novozym 435 as a catalyst and vinyl acetate as an acyl donor. Unlike the above compounds the 15-OH group of PGE2 was also acylated with a significant velocity under the same conditions. The enantiospecificity of the lipase-catalysed 11-acetylation of cloprostenol was established by separate treatment of(+)- and (-)-cloprostenols.Entities:
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Year: 1999 PMID： 10406654 DOI： 10.1016/s0960-894x(99)00295-4
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823