| Literature DB >> 10406652 |
J C Medina1, D Roche, B Shan, R M Learned, W P Frankmoelle, D L Clark, T Rosen, J C Jaen.
Abstract
In this report, we describe the synthesis of halogenated benzenesulfonamide compounds and their ability to inhibit the growth of HeLa, MCF-7 and MCF-7/ADR tumor cells in vitro. The multidrug resistance (MDR) phenotype of certain cells does not affect their sensitivity to these compounds. These agents belong to a family of compounds previously shown to bind irreversibly to cysteine-239 of beta-tubulin. Consistent with this mechanism of action, the cytotoxicities of these compounds appear to correlate with their ability to undergo nucleophilic aromatic substitution.Entities:
Mesh：
Substances：
Year: 1999 PMID： 10406652 DOI： 10.1016/s0960-894x(99)00276-0
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823