| Literature DB >> 10406646 |
W H Miller1, W E Bondinell, R D Cousins, K F Erhard, D R Jakas, R M Keenan, T W Ku, K A Newlander, S T Ross, R C Haltiwanger, J Bradbeer, F H Drake, M Gowen, S J Hoffman, S M Hwang, I E James, M W Lark, B Lechowska, D J Rieman, G B Stroup, J A Vasko-Moser, D L Zembryki, L M Azzarano, P C Adams, W F Huffman.
Abstract
A new series of potent nonpeptide vitronectin receptor antagonists, based on a novel carbocyclic Gly-Asp mimetic, has been discovered. A representative of this series, SB 265123 (4), has 100% oral bioavailability in rats, and is orally active in vivo in the ovariectomized rat model of osteoporosis.Entities:
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Year: 1999 PMID： 10406646 DOI： 10.1016/s0960-894x(99)00283-8
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823