Literature DB >> 10406637

Synthesis and identification of conformationally constrained selective MMP inhibitors.

J N Freskos1, J J McDonald, B V Mischke, P B Mullins, H S Shieh, R A Stegeman, A M Stevens.   

Abstract

We have discovered a new series of potent conformationally constrained MMP Inhibitors that are selective for MMP-13 over MMP-1.

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Year:  1999        PMID: 10406637     DOI: 10.1016/s0960-894x(99)00285-1

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  2 in total

1.  Characterization of an exosite binding inhibitor of matrix metalloproteinase 13.

Authors:  Lata T Gooljarsingh; Ami Lakdawala; Frank Coppo; Lusong Luo; Gregg B Fields; Peter J Tummino; Richard R Gontarek
Journal:  Protein Sci       Date:  2007-11-27       Impact factor: 6.725

2.  Active site ring-opening of a thiirane moiety and picomolar inhibition of gelatinases.

Authors:  Christopher Forbes; Qicun Shi; Jed F Fisher; Mijoon Lee; Dusan Hesek; Leticia I Llarrull; Marta Toth; Michael Gossing; Rafael Fridman; Shahriar Mobashery
Journal:  Chem Biol Drug Des       Date:  2009-10-06       Impact factor: 2.817

  2 in total

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