Sarcoplasmic reticulum in vascular cells in hypertension and during proliferation.

1. Multiple sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA) and two types of sarcoplasmic reticulum Ca2+ channels, the ryanodine receptor and the inositol 1,4,5 triphosphate (IP3) receptor are expressed. The heterogeneity of the Ca2+ pumps and Ca2+ channels in vascular cells will be discussed. 2. An age-related change in expression of the SERCA isoforms is observed in smooth muscle cells. 3. The sarcoplasmic reticulum Ca(2+)-uptake rate and the level of SERCA 2 mRNA are different in thoracic than in abdominal aortas and in aortas from spontaneously hypertensive rats than from normotensive rats. 4. Proliferation of vascular smooth muscle cells is associated with major changes in intracellular Ca(2+)-handling mechanisms.