Literature DB >> 10405638

Recent progress in P-glycoprotein research.

K Ueda1, A Yoshida, T Amachi.   

Abstract

P-glycoprotein can extrude a variety of structurally diverse, toxic xenobiotic compounds from cells. It is believed to be one of key molecules which can cause multidrug resistance in cancer. This paper deals with recent progress in P-glycoprotein research, especially in its structure, mechanisms for substrate recognition and transport. The review also discusses specific modulators of multidrug resistance in cancer and gene therapy using the MDR1 gene.

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Year:  1999        PMID： 10405638

Source DB:  PubMed          Journal:  Anticancer Drug Des        ISSN： 0266-9536


  12 in total

1.  Drug Interactions with Antiretrovirals.

Authors: 
Journal:  Curr Infect Dis Rep       Date:  2000-06       Impact factor: 3.725

2.  MDR1 genotype-related pharmacokinetics of digoxin after single oral administration in healthy Japanese subjects.

Authors:  T Sakaeda; T Nakamura; M Horinouchi; M Kakumoto; N Ohmoto; T Sakai; Y Morita; T Tamura; N Aoyama; M Hirai; M Kasuga; K Okumura
Journal:  Pharm Res       Date:  2001-10       Impact factor: 4.200

3.  MDR1 up-regulated by apoptotic stimuli suppresses apoptotic signaling.

Authors:  Toshiyuki Sakaeda; Tsutomu Nakamura; Midori Hirai; Takashi Kimura; Atsushi Wada; Tatsurou Yagami; Hironao Kobayashi; Shunji Nagata; Noboru Okamura; Takayoshi Yoshikawa; Toshiro Shirakawa; Akinobu Gotoh; Masafumi Matsuo; Katsuhiko Okumura
Journal:  Pharm Res       Date:  2002-09       Impact factor: 4.200

Review 4.  Intracellular cholesterol and phospholipid trafficking: comparable mechanisms in macrophages and neuronal cells.

Authors:  G Schmitz; E Orsó
Journal:  Neurochem Res       Date:  2001-09       Impact factor: 3.996

5.  Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein.

Authors:  Y Adachi; H Suzuki; Y Sugiyama
Journal:  Pharm Res       Date:  2001-12       Impact factor: 4.200

6.  Precipitous release of methyl-CpG binding protein 2 and histone deacetylase 1 from the methylated human multidrug resistance gene (MDR1) on activation.

Authors:  Assam El-Osta; Phillip Kantharidis; John R Zalcberg; Alan P Wolffe
Journal:  Mol Cell Biol       Date:  2002-03       Impact factor: 4.272

7.  Mechanisms of dexamethasone-induced disturbed sleep and fatigue in paediatric patients receiving treatment for ALL.

Authors:  Kelly Vallance; Wei Liu; Belinda N Mandrell; John C Panetta; Jami S Gattuso; Marilyn Hockenberry; Sue Zupanec; Lei Yang; Jie Yang; Pamela S Hinds
Journal:  Eur J Cancer       Date:  2010-04-17       Impact factor: 9.162

8.  Milk Phospholipids Enhance Lymphatic Absorption of Dietary Sphingomyelin in Lymph-Cannulated Rats.

Authors:  Masashi Morifuji; Seiichiro Higashi; Chisato Oba; Satomi Ichikawa; Keiko Kawahata; Taketo Yamaji; Hiroyuki Itoh; Yuki Manabe; Tatsuya Sugawara
Journal:  Lipids       Date:  2015-08-02       Impact factor: 1.880

Review 9.  Cholestasis.

Authors:  R Oude Elferink
Journal:  Gut       Date:  2003-05       Impact factor: 23.059

10.  miRNA profiles as a predictor of chemoresponsiveness in Wilms' tumor blastema.

Authors:  Jenny A Watson; Kenneth Bryan; Richard Williams; Sergey Popov; Gordan Vujanic; Aurore Coulomb; Liliane Boccon-Gibod; Norbert Graf; Kathy Pritchard-Jones; Maureen O'Sullivan
Journal:  PLoS One       Date:  2013-01-07       Impact factor: 3.240
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