Literature DB >> 10405328

HIV-1 Tat protein is poly(ADP-ribosyl)ated in vitro.

M Kameoka1, Y Tanaka, K Ota, A Itaya, K Yamamoto, K Yoshihara.   

Abstract

Purified recombinant HIV-1 Tat protein stimulated acceptor-dependent reaction of poly(ADP-ribose) polymerase in a dose-dependent manner. Analysis of the reaction products by SDS-polyacrylamide gel electrophoresis followed by immunoblotting with anti-poly(ADP-ribose) antibody revealed that recombinant Tat proteins were covalently modified with poly(ADP-ribose) in the enzyme reaction. Eventhough no significant effect of the modification was detected in the activity of Tat to form a specific complex with TAR (a viral transactivation response element) RNA, the present results raise the possibility that poly(ADP-ribose) polymerase is involved in the regulation of HIV-1 through the modification of a virus-encoded transactivator, Tat protein. Copyright 1999 Academic Press.

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Year:  1999        PMID： 10405328     DOI： 10.1006/bbrc.1999.0964

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  5 in total

1.  Role for human immunodeficiency virus type 1 Tat protein in suppression of viral reverse transcriptase activity during late stages of viral replication.

Authors:  M Kameoka; L Rong; M Götte; C Liang; R S Russell; M A Wainberg
Journal:  J Virol       Date:  2001-03       Impact factor: 5.103

2.  The Tat protein of human immunodeficiency virus type 1 (HIV-1) can promote placement of tRNA primer onto viral RNA and suppress later DNA polymerization in HIV-1 reverse transcription.

Authors:  Masanori Kameoka; Max Morgan; Marc Binette; Rodney S Russell; Liwei Rong; Xiaofeng Guo; Andrew Mouland; Lawrence Kleiman; Chen Liang; Mark A Wainberg
Journal:  J Virol       Date:  2002-04       Impact factor: 5.103

3.  Poly(ADP-ribose) polymerase-1 is required for efficient HIV-1 integration.

Authors:  H C Ha; K Juluri; Y Zhou; S Leung; M Hermankova; S H Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  2001-03-06       Impact factor: 11.205

4.  The dual action of poly(ADP-ribose) polymerase -1 (PARP-1) inhibition in HIV-1 infection: HIV-1 LTR inhibition and diminution in Rho GTPase activity.

Authors:  Slava Rom; Nancy L Reichenbach; Holly Dykstra; Yuri Persidsky
Journal:  Front Microbiol       Date:  2015-08-25       Impact factor: 5.640

5.  GigaAssay - An adaptable high-throughput saturation mutagenesis assay platform.

Authors:  Ronald Benjamin; Christopher J Giacoletto; Zachary T FitzHugh; Danielle Eames; Lindsay Buczek; Xiaogang Wu; Jacklyn Newsome; Mira V Han; Tony Pearson; Zhi Wei; Atoshi Banerjee; Lancer Brown; Liz J Valente; Shirley Shen; Hong-Wen Deng; Martin R Schiller
Journal:  Genomics       Date:  2022-07-26       Impact factor: 4.310
  5 in total

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