| Literature DB >> 10404612 |
T Chaly1, R Matacchieri, R Dahl, V Dhawan, D Eidelberg.
Abstract
A synthetic procedure for the routine preparation of [18F] N-3-fluoropropyl-2-beta-carbomethoxy-3-beta-(4' methylphenyl) nortropane (18F FPCMT) has been developed. The synthesis is based on alkylation of nortropane with 18F labeled fluoropropyl tosylate. Purification of the final product was achieved by a preparative HPLC procedure using Alltech Econosil column. Separation of the desired compound was achieved and the product was clean. The radiochemical yield (without decay correction) is 4 to 5%, calculated at the end of the synthesis based on the total amount of fluorine recovered from the target. Radiochemical purity was in the range of 98 to 99%.Entities:
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Year: 1999 PMID： 10404612 DOI： 10.1016/s0969-8043(99)00044-5
Source DB: PubMed Journal: Appl Radiat Isot ISSN： 0969-8043 Impact factor: 1.513