Proton magnetic resonance spectroscopy: clinical applications in children with nervous system diseases.

With the use of software modifications of existing magnetic resonance imaging technology, proton magnetic resonance spectroscopy yields insight noninvasively regarding brain biochemistry. Biochemical information can be obtained directly both regionally and longitudinally. This article summarizes the technological basis for magnetic resonance spectroscopy as well as its established applications to disorders of interest to the pediatric neurologist. Future directions for magnetic resonance spectroscopy study and advances to be expected in the near future are also highlighted.