Literature DB >> 10404243

Isolation of a novel microorganism, pestalotia heterocornis, producing paclitaxel

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Abstract

Pestalotia heterocornis was isolated from soil collected in yew forest and was shown to produce paclitaxel in semisynthetic liquid media. The presence of paclitaxel in the fungal extract was confirmed by FAB mass spectrometry and NMR spectroscopy. The maximum yield of paclitaxel was 31 &mgr;g per liter. Optimal paclitaxel production occurred after 5-7 days in a 20-liter scale fermentation at 23 degrees C. These results indicate that P. heterocornis is an excellent candidate for consideration in fermentation technology. Copyright 1999 John Wiley & Sons, Inc.

Entities:  

Year:  1999        PMID: 10404243     DOI: 10.1002/(sici)1097-0290(19990905)64:5<620::aid-bit13>3.0.co;2-w

Source DB:  PubMed          Journal:  Biotechnol Bioeng        ISSN: 0006-3592            Impact factor:   4.530


  4 in total

1.  Elimination of ergoline alkaloids following treatment of Ipomoea asarifolia (Convolvulaceae) with fungicides.

Authors:  Sabine Kucht; Julia Gross; Yasser Hussein; Torsten Grothe; Ullrich Keller; Simla Basar; Wilfried A König; Ulrike Steiner; Eckhard Leistner
Journal:  Planta       Date:  2004-04-15       Impact factor: 4.116

2.  A fungal endophyte induces transcription of genes encoding a redundant fungicide pathway in its host plant.

Authors:  Sameh S M Soliman; Christopher P Trobacher; Rong Tsao; John S Greenwood; Manish N Raizada
Journal:  BMC Plant Biol       Date:  2013-06-26       Impact factor: 4.215

3.  An endophytic Basidiomycete, Grammothele lineata, isolated from Corchorus olitorius, produces paclitaxel that shows cytotoxicity.

Authors:  Avizit Das; Mohammad Imtiazur Rahman; Ahlan Sabah Ferdous; Al- Amin; Mohammad Mahbubur Rahman; Nilufar Nahar; Md Aftab Uddin; Mohammad Riazul Islam; Haseena Khan
Journal:  PLoS One       Date:  2017-06-21       Impact factor: 3.240

4.  Interactions between Co-Habitating fungi Elicit Synthesis of Taxol from an Endophytic Fungus in Host Taxus Plants.

Authors:  Sameh S M Soliman; Manish N Raizada
Journal:  Front Microbiol       Date:  2013-01-22       Impact factor: 5.640

  4 in total

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