I del Rincón1, A Escalante. 1. The University of Texas Health Science Center at San Antonio, 78284, USA.
Abstract
OBJECTIVE: To study the genetics (HLA-DRB1 allele associations) of rheumatoid arthritis (RA) susceptibility and severity among Mexican Americans, an important, but understudied, US population. METHODS: HLA-DRB1 alleles were compared between 141 Mexican American patients with RA and 54 unrelated Mexican Americans without RA, and the association of these alleles with articular deformities and disability was examined. HLA-DRB1 alleles were typed using polymerase chain reaction-sequence-specific primer amplification and were classified according to the 1996 World Health Organization nomenclature. RESULTS: Of the 141 patients, 105 (74%) had at least 1 copy of the shared epitope (SE) sequence, compared with 29 (54%) of the 54 controls (P = 0.007). A significant gene-dose effect was observed, with 31 patients (22%) being homozygous for the SE compared with 1 (2%) of the controls (P = 0.004). In terms of disease severity, only 3% of RA patients who were "null" for the SE were outliers in the rate of development of articular deformities, compared with 10% of heterozygotes and 27% of homozygotes (P = 0.002). Patients who were DRB1*08 positive had significantly fewer deformities per year of disease and a slower rate of development of disability than did patients with other DRB1 alleles. CONCLUSION: HLA-DRB1 alleles containing the SE are associated with susceptibility to RA in Mexican Americans, and may also be associated with a more rapid development of articular deformities and disability. HLA-DRB1*08 appears to have a protective influence on RA susceptibility and disease severity in Mexican Americans.
OBJECTIVE: To study the genetics (HLA-DRB1 allele associations) of rheumatoid arthritis (RA) susceptibility and severity among Mexican Americans, an important, but understudied, US population. METHODS:HLA-DRB1 alleles were compared between 141 Mexican American patients with RA and 54 unrelated Mexican Americans without RA, and the association of these alleles with articular deformities and disability was examined. HLA-DRB1 alleles were typed using polymerase chain reaction-sequence-specific primer amplification and were classified according to the 1996 World Health Organization nomenclature. RESULTS: Of the 141 patients, 105 (74%) had at least 1 copy of the shared epitope (SE) sequence, compared with 29 (54%) of the 54 controls (P = 0.007). A significant gene-dose effect was observed, with 31 patients (22%) being homozygous for the SE compared with 1 (2%) of the controls (P = 0.004). In terms of disease severity, only 3% of RApatients who were "null" for the SE were outliers in the rate of development of articular deformities, compared with 10% of heterozygotes and 27% of homozygotes (P = 0.002). Patients who were DRB1*08 positive had significantly fewer deformities per year of disease and a slower rate of development of disability than did patients with other DRB1 alleles. CONCLUSION:HLA-DRB1 alleles containing the SE are associated with susceptibility to RA in Mexican Americans, and may also be associated with a more rapid development of articular deformities and disability. HLA-DRB1*08 appears to have a protective influence on RA susceptibility and disease severity in Mexican Americans.
Authors: S Laivoranta-Nyman; T Möttönen; R Hermann; J Tuokko; R Luukkainen; M Hakala; P Hannonen; M Korpela; U Yli-Kerttula; A Toivanen; J Ilonen Journal: Ann Rheum Dis Date: 2004-11 Impact factor: 19.103
Authors: Inmaculada del Rincón; Joseph F Polak; Daniel H O'Leary; Daniel F Battafarano; John M Erikson; Jose F Restrepo; Emily Molina; Agustín Escalante Journal: Ann Rheum Dis Date: 2014-05-20 Impact factor: 19.103
Authors: José Félix Restrepo; Inmaculada del Rincón; Daniel F Battafarano; Roy W Haas; Merced Doria; Agustín Escalante Journal: Clin Rheumatol Date: 2015-08-09 Impact factor: 2.980
Authors: N A Shadick; J E Heller; M E Weinblatt; N E Maher; J Cui; G Ginsburg; J Coblyn; R Anderson; D H Solomon; R Roubenoff; A Parker Journal: Ann Rheum Dis Date: 2007-05-09 Impact factor: 19.103
Authors: Laura B Hughes; Dahliann Morrison; James M Kelley; Miguel A Padilla; L Kelly Vaughan; Andrew O Westfall; Harshit Dwivedi; Ted R Mikuls; V Michael Holers; Lezlie A Parrish; Graciela S Alarcón; Doyt L Conn; Beth L Jonas; Leigh F Callahan; Edwin A Smith; Gary S Gilkeson; George Howard; Larry W Moreland; Nick Patterson; David Reich; S Louis Bridges Journal: Arthritis Rheum Date: 2008-02