Diagnosis of childhood acute myeloid leukemia.

Since 1985, our knowledge of the biology of acute leukemias has been greatly enhanced by new investigative tools and techniques. This new information in turn has produced improved diagnostic criteria, new classifications, and tailored therapeutic approaches for the acute leukemias. The intent of the following article is to present the clinical and laboratory features that facilitate a diagnosis of AML and provide insight into the biologic basis and treatment of these disorders.