K J Cho1, S S Lee, Y S Lee. 1. Department of Anatomic Pathology, Korea Cancer Center Hospital, 215-4 Gongneung-dong, Nowon-ku, Seoul 139-706, Korea.
Abstract
BACKGROUND: Adenoid cystic carcinoma (ACC) of the salivary gland shows a variable clinical course. It would be helpful to discover reliable biologic markers in the management of patients with ACC. METHODS: We examined proliferating cell nuclear antigen (PCNA) and c-erbB-2 oncoprotein expression on 30 cases of ACC of the salivary glands. The immunohistochemical results, and size, location, and histologic grade of the tumors were compared with the clinical outcome of the patients. RESULTS: Mean PCNA positivity of ACCs was 15%, and was higher in solid than in cribriform/tubular areas. High PCNA value was significantly correlated with shorter disease-free and overall survival of the patients with ACC. c-erbB-2 overexpression was observed in only five cases, focally in cribriform/tubular areas. High histologic grade, which was determined by the presence of solid components, showed a trend toward shorter survival. Size and location of ACC were not associated with patient outcome. CONCLUSIONS: The present study indicates that PCNA score may be one of the most useful prognostic factor of ACC. Copyright 1999 John Wiley & Sons, Inc. Head Neck 21: 414-419, 1999.
BACKGROUND:Adenoid cystic carcinoma (ACC) of the salivary gland shows a variable clinical course. It would be helpful to discover reliable biologic markers in the management of patients with ACC. METHODS: We examined proliferating cell nuclear antigen (PCNA) and c-erbB-2 oncoprotein expression on 30 cases of ACC of the salivary glands. The immunohistochemical results, and size, location, and histologic grade of the tumors were compared with the clinical outcome of the patients. RESULTS: Mean PCNA positivity of ACCs was 15%, and was higher in solid than in cribriform/tubular areas. High PCNA value was significantly correlated with shorter disease-free and overall survival of the patients with ACC. c-erbB-2 overexpression was observed in only five cases, focally in cribriform/tubular areas. High histologic grade, which was determined by the presence of solid components, showed a trend toward shorter survival. Size and location of ACC were not associated with patient outcome. CONCLUSIONS: The present study indicates that PCNA score may be one of the most useful prognostic factor of ACC. Copyright 1999 John Wiley & Sons, Inc. Head Neck 21: 414-419, 1999.
Authors: Markus Stenner; Ariane Demgensky; Christoph Molls; Aline Hardt; Jan C Luers; Maria Grosheva; Christian U Huebbers; Jens P Klussmann Journal: Eur Arch Otorhinolaryngol Date: 2011-08-27 Impact factor: 2.503
Authors: Laura Vidal; Ming S Tsao; Gregory R Pond; Ezra E W Cohen; Roger B Cohen; Eric X Chen; Mark Agulnik; Sebastien Hotte; Eric Winquist; Scott Laurie; D Neil Hayes; James Ho; Janet Dancey; Lillian L Siu Journal: Head Neck Date: 2009-08 Impact factor: 3.147