S Liu1, S W Wen, Y Mao, L Mery, J Rouleau. 1. Bureau of Reproductive and Child Health, Laboratory Centre for Disease Control, Ottawa, ON. shiliang_liu@hc-sc.gc.ca
Abstract
PURPOSE: To examine the pattern of testicular cancer incidence by age, time period and birth cohort since 1969 in Canada. METHODS: In addition to analyses of the secular trends by age group and birth cohort separately, an age-period-cohort model and the submodels with standard Poisson assumptions were fitted to the data. RESULTS: The overall age-adjusted incidence of testicular cancer increased in Canada, from 2.8 per 100,000 males in 1969-71 to 4.2 in 1991-93. The younger age groups showed much higher absolute incidence rates in the recent period compared with those in the early period. Age-period-cohort modelling of data restricted to males aged 20-84 years suggested that the observed increase in testicular cancer could be largely attributed to a birth cohort effect. A steady increase in risk was observed among men born since 1945; those born between 1959 and 1968 were 2.0 (95% CI, 1.5-2.6) times as likely to develop testicular cancer as those born between 1904 and 1913. CONCLUSION: The risk of testicular cancer has increased over time and changing exposure to environmental factors early in life may be responsible for this.
PURPOSE: To examine the pattern of testicular cancer incidence by age, time period and birth cohort since 1969 in Canada. METHODS: In addition to analyses of the secular trends by age group and birth cohort separately, an age-period-cohort model and the submodels with standard Poisson assumptions were fitted to the data. RESULTS: The overall age-adjusted incidence of testicular cancer increased in Canada, from 2.8 per 100,000 males in 1969-71 to 4.2 in 1991-93. The younger age groups showed much higher absolute incidence rates in the recent period compared with those in the early period. Age-period-cohort modelling of data restricted to males aged 20-84 years suggested that the observed increase in testicular cancer could be largely attributed to a birth cohort effect. A steady increase in risk was observed among men born since 1945; those born between 1959 and 1968 were 2.0 (95% CI, 1.5-2.6) times as likely to develop testicular cancer as those born between 1904 and 1913. CONCLUSION: The risk of testicular cancer has increased over time and changing exposure to environmental factors early in life may be responsible for this.
Authors: Georg Hrivatakis; Wolfgang Astfalk; Andreas Schmidt; Andreas Hartwig; Thomas Kugler; Thomas Heim; Axel Clausner; Albrecht Frunder; Harduin Weber; Steffan Loff; Joerg Fuchs; Verena Ellerkamp Journal: Dtsch Arztebl Int Date: 2014-09-26 Impact factor: 5.594
Authors: Brooke L Magnanti; M Tevfik Dorak; Louise Parker; Alan W Craft; Peter W James; Richard Jq McNally Journal: BMC Cancer Date: 2008-04-03 Impact factor: 4.430