Multiple-voxel double-quantum lactate-edited spectroscopy using two-dimensional longitudinal Hadamard encoding.

A conventional gradient-selected double-quantum lactate editing sequence was combined with fourth order two-dimensional longitudinal Hadamard encoding and slice-selective refocusing to acquire lactate-edited spectra in a 3 x 3 matrix of voxels. The performance of the sequence was verified in phantoms at 9.4 T and in focally ischemic rat brain at 7.0 T. Efficient suppression of water, lipid, and the singlet resonances of creatine, choline, and N-acetylaspartate was achieved, giving multi-voxel localized lactate-edited spectra with good signal-to-noise ratio.