| Literature DB >> 10397900 |
T Peltola1, M Jokinen, H Rahiala, E Levänen, J B Rosenholm, I Kangasniemi, A Yli-Urpo.
Abstract
Sol-gel-derived SiO2 and CaO-P2O5-SiO2 have been shown to be bioactive and bone bonding. In this study bioactive sol-gel-derived SiO2 and CaO-P2O5-SiO2 systems were tested for in in vitro bioactivity. The calcined ceramic monoliths were immersed in a simulated body fluid and analyzed to follow the hydroxyapatite formation on the ceramic surface. Apatite-forming ability was investigated in terms of structural changes by changing the composition and the preparation method. The role of Ca and P dopants in the substrate structure is complicated, and careful characterization is needed. The composition and structure together determine the in vitro bioactivity. The pore structure was analyzed using N2-adsorption/desorption isotherms. The results indicate that a great mesopore volume and a wide mesopore size distribution favor hydroxycarbonate apatite nucleation and a great surface area is not needed. The performed preparation process for silica in a basic environment provides a convenient way to prepare a mesoporous material. Copyright 1999 John Wiley & Sons, Inc.Entities:
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Year: 1999 PMID： 10397900 DOI： 10.1002/(sici)1097-4636(199901)44:1<12::aid-jbm2>3.0.co;2-e
Source DB: PubMed Journal: J Biomed Mater Res ISSN： 0021-9304