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Literature DB >> 10397504

Synthesis and evaluation of 1-position-modified inositol 1,4,5-trisphosphate analogs.

T Inoue¹, K Kikuchi, K Hirose, M Iino, T Nagano.

Abstract

IP3 analogs were synthesized by the modification of phosphate at the 1-position, and their affinity for the IP3 receptor was analyzed by means of surface plasmon resonance measurements. Our results suggest that a hydrophobic and charged moiety linked to this position enhances the affinity for the IP3 receptor.

Entities: Chemical Gene

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Year: 1999 PMID： 10397504 DOI： 10.1016/s0960-894x(99)00256-5

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

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Cited

6 in total

1. Phosphatidylinositol 3,4,5-trisphosphate activity probes for the labeling and proteomic characterization of protein binding partners.

Authors: Meng M Rowland; Heidi E Bostic; Denghuang Gong; Anna E Speers; Nathan Lucas; Wonhwa Cho; Benjamin F Cravatt; Michael D Best
Journal: Biochemistry Date: 2011-11-30 Impact factor: 3.162

2. Selective photoinactivation of protein function through environment-sensitive switching of singlet oxygen generation by photosensitizer.

Authors: Takatoshi Yogo; Yasuteru Urano; Akiko Mizushima; Hisato Sunahara; Takanari Inoue; Kenzo Hirose; Masamitsu Iino; Kazuya Kikuchi; Tetsuo Nagano
Journal: Proc Natl Acad Sci U S A Date: 2008-01-02 Impact factor: 11.205

3. Microarray analysis of Akt PH domain binding employing synthetic biotinylated analogs of all seven phosphoinositide headgroup isomers.

Authors: Meng M Rowland; Denghuang Gong; Heidi E Bostic; Nathan Lucas; Wonhwa Cho; Michael D Best
Journal: Chem Phys Lipids Date: 2011-12-08 Impact factor: 3.329

Synthesis and evaluation of 1-position-modified inositol 1,4,5-trisphosphate analogs.

1. Phosphatidylinositol 3,4,5-trisphosphate activity probes for the labeling and proteomic characterization of protein binding partners.

2. Selective photoinactivation of protein function through environment-sensitive switching of singlet oxygen generation by photosensitizer.

3. Microarray analysis of Akt PH domain binding employing synthetic biotinylated analogs of all seven phosphoinositide headgroup isomers.

4. Analysis of protein-ligand interactions by fluorescence polarization.

5. Stimulation of inositol 1,4,5-trisphosphate (IP3) receptor subtypes by analogues of IP3.

Review 6. Controllable Photodynamic Therapy Implemented by Regulating Singlet Oxygen Efficiency.