| Literature DB >> 10397497 |
D Lee1, J L Adams, M Brandt, W E DeWolf, P M Keller, M A Levy.
Abstract
An efficient strategy for the synthesis of a tetrapeptidyl substrate combinatorial array directed toward the caspases is described. Testing of this array with caspases 1 and 4 gave substrate hydrolytic profiles characteristic of each caspase, and permitted the identification of efficiently processed substrates. A comparison of this approach to that using a positional scanning library is presented.Entities:
Mesh：
Substances：
Year: 1999 PMID： 10397497 DOI： 10.1016/s0960-894x(99)00260-7
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823