Literature DB >> 103968

The relative immunogenicity in mice of whole and split influenza virus.

S S Gandhi.   

Abstract

The relative immunogenicity in mice of whole influenza virus, and virus split with different disrupting agents, was compared. Using the single radial immunodiffusion test to estimate the haemagglutinin antigen concentration in different virus preparations, it was found that, in general, split virus preparations induced substantially lower titres of HI antibody in mice than whole virus after one or two injections of the antigen.

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Year:  1978        PMID： 103968      PMCID： PMC2130058          DOI： 10.1017/s0022172400025213

Source DB:  PubMed          Journal:  J Hyg (Lond)        ISSN： 0022-1724


  10 in total

1.  COMPARISONS OF SEROLOGIC AND FEBRILE RESPONSES IN HUMANS TO VACCINATION WITH INFLUENZA A VIRUSES OR THEIR HEMAGGLUTININS.

Authors:  F M DAVENPORT; A V HENNESSY; F M BRANDON; R G WEBSTER; C D BARRETT; G O LEASE
Journal:  J Lab Clin Med       Date:  1964-01

2.  The use of V. cholerae filtrates in the destruction of non-specific inhibitor in ferret sera.

Authors:  A ISAACS; A BOZZO
Journal:  Br J Exp Pathol       Date:  1951-08

3.  Comparative trial of influenza vaccines. I. Immunogenicity of whole virus and split product vaccines in man.

Authors:  D W Barry; R E Mayner; E Staton; R C Dunlap; S C Rastogi; J E Hannah; R J Blackburn; D F Nortman; P R Graze
Journal:  Am J Epidemiol       Date:  1976-07       Impact factor: 4.897

4.  Studies on immunological paralysis. V. The influence of molecular weight on the immunogenicity, tolerogenicity and antibody-neutralizing activity of the 3 pneumococcal polysaccharide.

Authors:  J G Howard; H Zola; G H Christie; B M Courtenay
Journal:  Immunology       Date:  1971-09       Impact factor: 7.397

5.  Inactivated influenza vaccine efficacy: diminished antigenicity of split-product vaccines in mice.

Authors:  D W Barry; E Staton; R E Mayner
Journal:  Infect Immun       Date:  1974-12       Impact factor: 3.441

6.  Antigenic enhancement of ether-extracted influenza virus vaccines by AIPO4.

Authors:  F M Davenport
Journal:  Proc Soc Exp Biol Med       Date:  1968-02

7.  Elicitation of antibody response against influenza viruses by different viral subunit preparations.

Authors:  B A Rubin; W A Pierzchala; A R Neurath
Journal:  Arch Gesamte Virusforsch       Date:  1967

8.  A single-radial-immunodiffusion technique for the assay of influenza haemagglutinin antigen. Proposals for an assay method for the haemagglutinin content of influenza vaccines.

Authors:  G C Schild; J M Wood; R W Newman
Journal:  Bull World Health Organ       Date:  1975       Impact factor: 9.408

9.  Crystalline antigen from the influenza virus envelope.

Authors:  C M Brand; J J Skehel
Journal:  Nat New Biol       Date:  1972-08-02

10.  Influenza virus subunit vaccines: immunogenicity and lack of toxicity for rabbits of ether- and detergent-disrupted virus.

Authors:  R G Webster; W G Laver
Journal:  J Immunol       Date:  1966-04       Impact factor: 5.422
  10 in total

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