Literature DB >> 10396412

Combination therapy for chronic hepatitis C: interferon and ribavirin.

J M Christie1, R W Chapman.   

Abstract

Hepatitis C virus (HCV) infection is one of the commonest causes of liver cirrhosis and hepatocellular carcinoma. This review deals with treatment of chronic HCV infection with a combination of interferon and ribavirin. Recent trials have shown that approximately 40% of patients will clear HCV with combination treatment. This is an important advance in the treatment of this serious viral infection.

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Year:  1999        PMID： 10396412     DOI： 10.12968/hosp.1999.60.5.1116

Source DB:  PubMed          Journal:  Hosp Med        ISSN： 1462-3935


  4 in total

1.  Trans-splicing group I intron targeting hepatitis C virus IRES mediates cell death upon viral infection in Huh7.5 cells.

Authors:  Pruksa Nawtaisong; Mark E Fraser; James R Carter; Malcolm J Fraser
Journal:  Virology       Date:  2015-04-07       Impact factor: 3.616

2.  Interferons activate the p42/44 mitogen-activated protein kinase and JAK-STAT (Janus kinase-signal transducer and activator transcription factor) signalling pathways in hepatocytes: differential regulation by acute ethanol via a protein kinase C-dependent mechanism.

Authors:  V A Nguyen; J Chen; F Hong; E J Ishac; B Gao
Journal:  Biochem J       Date:  2000-07-15       Impact factor: 3.857

3.  Interference of hepatitis C virus RNA replication by short interfering RNAs.

Authors:  Sharookh B Kapadia; Amy Brideau-Andersen; Francis V Chisari
Journal:  Proc Natl Acad Sci U S A       Date:  2003-02-03       Impact factor: 11.205

4.  Consensus siRNA for inhibition of HCV genotype-4 replication.

Authors:  Abdel Rahman N Zekri; Abeer A Bahnassy; Hanaa M Alam El-Din; Hosny M Salama
Journal:  Virol J       Date:  2009-01-27       Impact factor: 4.099
  4 in total

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