Literature DB >> 10395519

Interference of linoleic acid fraction in some receptor binding assays.

K Ingkaninan1, J K von Frijtag Drabbe Künzel, A P IJzerman, R Verpoorte.   

Abstract

An extract of a suspension culture of Tabernaemontana pandacaqui Poir. was fractionated by centrifugal partition chromatography. Aliquots were tested in an adenosine A1 receptor binding assay. This led to the isolation and identification of linoleic acid, which proved to be a noncompetitive inhibitor. This "false positive"effect also extended to some other binding assays.

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Year:  1999        PMID: 10395519     DOI: 10.1021/np9805490

Source DB:  PubMed          Journal:  J Nat Prod        ISSN: 0163-3864            Impact factor:   4.050


  5 in total

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2.  Opioidergic mechanisms underlying the actions of Vitex agnus-castus L.

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4.  Fatty acids with in vitro binding affinity for human opioid receptors from the fungus Emericella nidulans.

Authors:  Amer H Tarawneh; Francisco León; Mohamed M Radwan; Xiaoning Wang; Olivia R Dale; Afeef S Husni; Luiz H Rosa; Stephen J Cutler
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Review 5.  Can Invalid Bioactives Undermine Natural Product-Based Drug Discovery?

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  5 in total

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