Literature DB >> 10395496

Synthetic analogues of irlbacholine: a novel antifungal plant metabolite isolated from Irlbachia alata.

Q Lu1, R P Ubillas, Y Zhou, L G Dubenko, J M Dener, J Litvak, P W Phuan, M Flores, Z Ye, R E Gerber, T Truong, D E Bierer.   

Abstract

Irlbacholine and a series of related analogues were synthesized and their antifungal activities against Candida albicans, Cryptococcus neoformans, and Aspergillus fumigatus were assessed. The natural bisphosphocholine, irlbacholine, was the most potent compound, its 22-carbon chain length appearing to be optimal.

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Year:  1999        PMID: 10395496     DOI: 10.1021/np980425n

Source DB:  PubMed          Journal:  J Nat Prod        ISSN: 0163-3864            Impact factor:   4.050


  3 in total

1.  Hexadecylphosphocholine (miltefosine) has broad-spectrum fungicidal activity and is efficacious in a mouse model of cryptococcosis.

Authors:  Fred Widmer; Lesley C Wright; Daniel Obando; Rosemary Handke; Ranjini Ganendren; David H Ellis; Tania C Sorrell
Journal:  Antimicrob Agents Chemother       Date:  2006-02       Impact factor: 5.191

2.  Synthesis and antifungal activities of miltefosine analogs.

Authors:  Ranga Rao Ravu; Ying-Lien Chen; Melissa R Jacob; Xuewen Pan; Ameeta K Agarwal; Shabana I Khan; Joseph Heitman; Alice M Clark; Xing-Cong Li
Journal:  Bioorg Med Chem Lett       Date:  2013-07-06       Impact factor: 2.823

3.  Inherited biotic protection in a neotropical pioneer plant.

Authors:  Alain Dejean; Bruno Corbara; Céline Leroy; Jacques H C Delabie; Vivien Rossi; Régis Céréghino
Journal:  PLoS One       Date:  2011-03-31       Impact factor: 3.240

  3 in total

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