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Literature DB >> 10394418

New drugs for BNCT: an experimental approach.

L Weissfloch¹, M Bremer, P Lemmen, T Probst, M Wagner, M Peller, T Auberger, R Senekowitsch-Schmidtke, K Tempel, M Molls.

Abstract

New kinds of boron-containing drugs were developed and tested in several murine tumor models. The boron-containing ether lipid B-Et-11-OMe was injected in mammary carcinoma (AT17) and osteosarcoma (OTS-64) bearing mice. Furthermore boron-substituted ferrocenium derivatives were tested. Two were excessively toxic; the third could be investigated. Boron accumulation and time-dependent biodistribution were determined using alpha-particle sensitive films and inductively coupled plasma-atomic emission pectrometry (ICP-AES) and -mass spectrometry (ICP-MS) of tumors, organs and tissues. Additionally, a new method of boron detection by NMR is in preparation.

Entities: Chemical Disease Species

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Year: 1999 PMID： 10394418 DOI： 10.1007/bf03038909

Source DB: PubMed Journal: Strahlenther Onkol ISSN： 0179-7158 Impact factor: 3.621

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References

19 in total

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New drugs for BNCT: an experimental approach.

1. Liposome preparation and size characterization.

2. Quantitative neutron capture radiography for boron in biological specimens.

3. Oxygen tensions in rodent tumors after irradiation with neutrons.

4. New carborane-based compounds for boron neutron capture therapy: binding and toxicity of ANC-1, DAC-1 and B-Et-11-OMe in cultured human glioma and mouse melanoma cells.

5. Uptake and distribution of the boron-containing ether lipid B-Et-11-OMe in tumor-bearing mice.

6. Selective localization of a radioiodinated phospholipid ether analog in human tumor xenografts.

Review 7. Present status of boron neutron capture therapy.

8. Oxygen-induced MR signal changes in murine tumors.

Review 9. Membrane-interactive lipids as experimental anticancer drugs.

10. Pharmacokinetics in melanoma-bearing mice of 5-dihydroxyboryl-6-propyl-2-thiouracil (BPTU), a candidate compound for boron neutron capture therapy.