R O Wright1, M W Shannon, R J Wright, H Hu. 1. Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass. 02115, USA. robert.wright@channing.harvard.edu
Abstract
OBJECTIVES: The purpose of this study was to examine the association between iron deficiency and low-level lead poisoning. METHODS: Data were collected in an urban primary care clinic from 3650 children aged 9 to 48 months. Iron deficiency was defined as a red cell mean corpuscular volume (MCV) of less than 70 fL and a red cell distribution width (RDW) of more than 14.5 in children younger than 2 years, and an MCV of less than 73 fL and RDW of more than 14.5 in those 2 years or older. RESULTS: After adjustment for age, hemoglobin concentration, and insurance status, the odds ratios for iron deficiency predicting blood lead levels greater than or equal to 5 micrograms/dL and greater than or equal to 10 micrograms/dL were 1.63 (95% confidence interval [CI] = 1.29, 2.04) and 1.44 (95% CI = 1.004, 2.05). CONCLUSIONS: Iron deficiency is significantly associated with low-level lead poisoning in children aged 9 to 48 months.
OBJECTIVES: The purpose of this study was to examine the association between iron deficiency and low-level lead poisoning. METHODS: Data were collected in an urban primary care clinic from 3650 children aged 9 to 48 months. Iron deficiency was defined as a red cell mean corpuscular volume (MCV) of less than 70 fL and a red cell distribution width (RDW) of more than 14.5 in children younger than 2 years, and an MCV of less than 73 fL and RDW of more than 14.5 in those 2 years or older. RESULTS: After adjustment for age, hemoglobin concentration, and insurance status, the odds ratios for iron deficiency predicting blood lead levels greater than or equal to 5 micrograms/dL and greater than or equal to 10 micrograms/dL were 1.63 (95% confidence interval [CI] = 1.29, 2.04) and 1.44 (95% CI = 1.004, 2.05). CONCLUSIONS:Iron deficiency is significantly associated with low-level lead poisoning in children aged 9 to 48 months.
Authors: Bruce P Lanphear; Richard W Hornung; Jane Khoury; Kim N Dietrich; Deborah A Cory-Slechta; Richard L Canfield Journal: Sci Total Environ Date: 2008-03-07 Impact factor: 7.963
Authors: Gauri Desai; Gabriel Barg; Marie Vahter; Elena I Queirolo; Fabiana Peregalli; Nelly Mañay; Amy E Millen; Jihnhee Yu; Richard W Browne; Katarzyna Kordas Journal: Int J Hyg Environ Health Date: 2019-10-03 Impact factor: 5.840
Authors: Marianne R Hopkins; Adrienne S Ettinger; Mauricio Hernández-Avila; Joel Schwartz; Martha María Téllez-Rojo; Héctor Lamadrid-Figueroa; David Bellinger; Howard Hu; Robert O Wright Journal: Environ Health Perspect Date: 2008-09 Impact factor: 9.031