Peptic-ulcer disease in the elderly.

Peptic-ulcer disease causes significant morbidity and mortality in the elderly. It frequently presents in an atypical manner and is associated with a high incidence of complications. The prevalence of Helicobacter pylori increases with age and can have an important role in the development of ulcers. Nonsteroidal anti-inflammatory drugs also contribute to the increased incidence of ulcers and the development of complications in the elderly. Although management of ulcer disease in the elderly is similar to that in the younger population, consideration must be given to the potential for increased incidence of side effects and medication interactions. When endoscopy and surgery are performed there should be an appreciation for the risks associated with concurrent illnesses that can accompany advanced age.