Literature DB >> 10393385

Decreased glomerular proteinase activity in the streptozotocin diabetic rat.

R H Song1, A K Singh, D J Leehey.   

Abstract

Decreased glomerular proteinase activity may contribute to matrix accumulation in diabetes. Male Sprague-Dawley rats were rendered diabetic by injection of streptozotocin (STZ) 65 mg/kg i.v.; age-matched, sham-injected rats served as controls. Glomeruli from diabetic rats 1 month after STZ injection demonstrated significant decreases in collagenase and cathepsin B activities compared to control glomeruli. Treatment with insulin resulted in a slight (but not significant) increase in collagenase activity and normalized cathepsin B activity. We conclude that decreased glomerular collagenase and cathepsin B activities are present in STZ diabetes. These alterations may contribute to mesangial matrix accumulation.

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Year:  1999        PMID： 10393385     DOI： 10.1159/000013492

Source DB:  PubMed          Journal:  Am J Nephrol        ISSN： 0250-8095            Impact factor:   3.754


  7 in total

1.  Methylglyoxal induces hyperpermeability of the blood-retinal barrier via the loss of tight junction proteins and the activation of matrix metalloproteinases.

Authors:  Junghyun Kim; Chan-Sik Kim; Yun Mi Lee; Kyuhyung Jo; So Dam Shin; Jin Sook Kim
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2.  Evidence for inactivation of cysteine proteases by reactive carbonyls via glycation of active site thiols.

Authors:  Jingmin Zeng; Rachael A Dunlop; Kenneth J Rodgers; Michael J Davies
Journal:  Biochem J       Date:  2006-09-01       Impact factor: 3.857

3.  Inhibition of diabetic nephropathy by a decoy peptide corresponding to the "handle" region for nonproteolytic activation of prorenin.

Authors:  Atsuhiro Ichihara; Matsuhiko Hayashi; Yuki Kaneshiro; Fumiaki Suzuki; Tsutomu Nakagawa; Yuko Tada; Yukako Koura; Akira Nishiyama; Hirokazu Okada; M Nasir Uddin; A H M Nurun Nabi; Yuichi Ishida; Tadashi Inagami; Takao Saruta
Journal:  J Clin Invest       Date:  2004-10       Impact factor: 14.808

Review 4.  Matrix metalloproteinases: their potential role in the pathogenesis of diabetic nephropathy.

Authors:  Kathryn M Thrailkill; R Clay Bunn; John L Fowlkes
Journal:  Endocrine       Date:  2008-10-30       Impact factor: 3.633

5.  Proteases and protease inhibitors of urinary extracellular vesicles in diabetic nephropathy.

Authors:  Luca Musante; Dorota Tataruch; Dongfeng Gu; Xinyu Liu; Carol Forsblom; Per-Henrik Groop; Harry Holthofer
Journal:  J Diabetes Res       Date:  2015-03-19       Impact factor: 4.011

Review 6.  Retinal capillary basement membrane thickening: Role in the pathogenesis of diabetic retinopathy.

Authors:  Sayon Roy; Dongjoon Kim
Journal:  Prog Retin Eye Res       Date:  2020-09-18       Impact factor: 21.198

7.  Glibenclamide induces collagen IV catabolism in high glucose-stimulated mesangial cells.

Authors:  Liping Zhu; Pedro Cortes; Clare Hassett; David W Taube; Jerry Yee
Journal:  Exp Diabetes Res       Date:  2012-09-12
  7 in total

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