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Literature DB >> 10390238

Characterization of new mutations in pyrazinamide-resistant strains of Mycobacterium tuberculosis and identification of conserved regions important for the catalytic activity of the pyrazinamidase PncA.

N Lemaitre¹, W Sougakoff, C Truffot-Pernot, V Jarlier.

Abstract

A new set of mutations, including transposition of the insertion sequence IS6110, was identified in the pncA gene from 19 pyrazinamide-resistant Mycobacterium tuberculosis strains. Alignment of the PncA protein from M. tuberculosis with homologous proteins from different bacterial species revealed three highly conserved regions in PncA which may play an important role in the processing of pyrazinamide.

Entities: Chemical Species

Mesh：

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Year: 1999 PMID： 10390238 PMCID： PMC89359

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

11 in total

1. Genotypic characterization of drug-resistant Mycobacterium tuberculosis isolates from Peru.

Authors: P Escalante; S Ramaswamy; H Sanabria; H Soini; X Pan; O Valiente-Castillo; J M Musser
Journal: Tuber Lung Dis Date: 1998

2. Crystal structure analysis, refinement and enzymatic reaction mechanism of N-carbamoylsarcosine amidohydrolase from Arthrobacter sp. at 2.0 A resolution.

Authors: M J Romão; D Turk; F X Gomis-Rüth; R Huber; G Schumacher; H Möllering; L Rüssmann
Journal: J Mol Biol Date: 1992-08-20 Impact factor: 5.469

3. Insertion element IS987 from Mycobacterium bovis BCG is located in a hot-spot integration region for insertion elements in Mycobacterium tuberculosis complex strains.

Authors: P W Hermans; D van Soolingen; E M Bik; P E de Haas; J W Dale; J D van Embden
Journal: Infect Immun Date: 1991-08 Impact factor: 3.441

4. Simple pyrazinamidase and urease tests for routine identification of mycobacteria.

Authors: L G Wayne
Journal: Am Rev Respir Dis Date: 1974-01

5. Characterization of pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis.

Authors: A Scorpio; P Lindholm-Levy; L Heifets; R Gilman; S Siddiqi; M Cynamon; Y Zhang
Journal: Antimicrob Agents Chemother Date: 1997-03 Impact factor: 5.191

6. Mutations associated with pyrazinamide resistance in pncA of Mycobacterium tuberculosis complex organisms.

Authors: S Sreevatsan; X Pan; Y Zhang; B N Kreiswirth; J M Musser
Journal: Antimicrob Agents Chemother Date: 1997-03 Impact factor: 5.191

7. A Mycobacterium tuberculosis IS6110 preferential locus (ipl) for insertion into the genome.

Authors: Z Fang; K J Forbes
Journal: J Clin Microbiol Date: 1997-02 Impact factor: 5.948

8. Mutations in pncA, a gene encoding pyrazinamidase/nicotinamidase, cause resistance to the antituberculous drug pyrazinamide in tubercle bacillus.

Authors: A Scorpio; Y Zhang
Journal: Nat Med Date: 1996-06 Impact factor: 53.440

9. Mutation in pncA is a major mechanism of pyrazinamide resistance in Mycobacterium tuberculosis.

Authors: K Hirano; M Takahashi; Y Kazumi; Y Fukasawa; C Abe
Journal: Tuber Lung Dis Date: 1997

10. Differences in the prevalence of IS6110 insertion sites in Mycobacterium tuberculosis strains: low and high copy number of IS6110.

Authors: N Fomukong; M Beggs; H el Hajj; G Templeton; K Eisenach; M D Cave
Journal: Tuber Lung Dis Date: 1997

49 in total

10. Peruvian and globally reported amino acid substitutions on the Mycobacterium tuberculosis pyrazinamidase suggest a conserved pattern of mutations associated to pyrazinamide resistance.

Authors: Mirko Zimic; Patricia Sheen; Miguel Quiliano; Andrés Gutierrez; Robert H Gilman
Journal: Infect Genet Evol Date: 2009-12-04 Impact factor: 3.342

Characterization of new mutations in pyrazinamide-resistant strains of Mycobacterium tuberculosis and identification of conserved regions important for the catalytic activity of the pyrazinamidase PncA.

1. Genotypic characterization of drug-resistant Mycobacterium tuberculosis isolates from Peru.

2. Crystal structure analysis, refinement and enzymatic reaction mechanism of N-carbamoylsarcosine amidohydrolase from Arthrobacter sp. at 2.0 A resolution.

3. Insertion element IS987 from Mycobacterium bovis BCG is located in a hot-spot integration region for insertion elements in Mycobacterium tuberculosis complex strains.

4. Simple pyrazinamidase and urease tests for routine identification of mycobacteria.

5. Characterization of pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis.

6. Mutations associated with pyrazinamide resistance in pncA of Mycobacterium tuberculosis complex organisms.

7. A Mycobacterium tuberculosis IS6110 preferential locus (ipl) for insertion into the genome.

8. Mutations in pncA, a gene encoding pyrazinamidase/nicotinamidase, cause resistance to the antituberculous drug pyrazinamide in tubercle bacillus.

9. Mutation in pncA is a major mechanism of pyrazinamide resistance in Mycobacterium tuberculosis.

10. Differences in the prevalence of IS6110 insertion sites in Mycobacterium tuberculosis strains: low and high copy number of IS6110.

Review 1. Evolution of drug resistance in Mycobacterium tuberculosis: clinical and molecular perspective.

2. Correlation between pyrazinamide activity and pncA mutations in Mycobacterium tuberculosis isolates in Taiwan.

3. pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis isolates in Portugal.

4. Spectrum of pncA mutations in multidrug-resistant Mycobacterium tuberculosis isolates obtained in Latvia.

5. Pyrazinoic acid efflux rate in Mycobacterium tuberculosis is a better proxy of pyrazinamide resistance.

6. Characterization of pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis in Brazil.

Review 7. Modes and modulations of antibiotic resistance gene expression.

8. Kinetics and inhibition of nicotinamidase from Mycobacterium tuberculosis.

9. Widespread pyrazinamide-resistant Mycobacterium tuberculosis family in a low-incidence setting.

10. Peruvian and globally reported amino acid substitutions on the Mycobacterium tuberculosis pyrazinamidase suggest a conserved pattern of mutations associated to pyrazinamide resistance.