Literature DB >> 10390236

Effect of fluoroquinolone concentration on selection of resistant mutants of Mycobacterium bovis BCG and Staphylococcus aureus.

Y Dong1, X Zhao, J Domagala, K Drlica.   

Abstract

When Mycobacterium bovis BCG and Staphylococcus aureus were plated on agar containing increasing concentrations of fluoroquinolone, colony numbers exhibited a sharp drop, followed by a plateau and a second sharp drop. The plateau region correlated with the presence of first-step resistant mutants. Mutants were not recovered at concentrations above those required for the second sharp drop, thereby defining a mutant prevention concentration (MPC). A C-8-methoxy group lowered the MPC for an N-1-cyclopropyl fluoroquinolone.

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Year:  1999        PMID： 10390236      PMCID： PMC89357     

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  14 in total

Review 1.  Genetic systems for mycobacteria.

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Journal:  Methods Enzymol       Date:  1991       Impact factor: 1.600

Review 2.  DNA gyrase, topoisomerase IV, and the 4-quinolones.

Authors:  K Drlica; X Zhao
Journal:  Microbiol Mol Biol Rev       Date:  1997-09       Impact factor: 11.056

3.  Studies on plasmid replication. I. Plasmid incompatibility and establishment in Staphylococcus aureus.

Authors:  R P Novick; R Brodsky
Journal:  J Mol Biol       Date:  1972-07-21       Impact factor: 5.469

4.  N-1-tert-butyl-substituted quinolones: in vitro anti-Mycobacterium avium activities and structure-activity relationship studies.

Authors:  G Klopman; D Fercu; T E Renau; M R Jacobs
Journal:  Antimicrob Agents Chemother       Date:  1996-11       Impact factor: 5.191

5.  Differential behaviors of Staphylococcus aureus and Escherichia coli type II DNA topoisomerases.

Authors:  F Blanche; B Cameron; F X Bernard; L Maton; B Manse; L Ferrero; N Ratet; C Lecoq; A Goniot; D Bisch; J Crouzet
Journal:  Antimicrob Agents Chemother       Date:  1996-12       Impact factor: 5.191

6.  Fluoroquinolone action against mycobacteria: effects of C-8 substituents on growth, survival, and resistance.

Authors:  Y Dong; C Xu; X Zhao; J Domagala; K Drlica
Journal:  Antimicrob Agents Chemother       Date:  1998-11       Impact factor: 5.191

7.  Quinolone resistance mutations in topoisomerase IV: relationship to the flqA locus and genetic evidence that topoisomerase IV is the primary target and DNA gyrase is the secondary target of fluoroquinolones in Staphylococcus aureus.

Authors:  E Y Ng; M Trucksis; D C Hooper
Journal:  Antimicrob Agents Chemother       Date:  1996-08       Impact factor: 5.191

8.  Cloning and primary structure of Staphylococcus aureus DNA topoisomerase IV: a primary target of fluoroquinolones.

Authors:  L Ferrero; B Cameron; B Manse; D Lagneaux; J Crouzet; A Famechon; F Blanche
Journal:  Mol Microbiol       Date:  1994-08       Impact factor: 3.501

9.  Structure-activity relationships of the quinolone antibacterials against mycobacteria: effect of structural changes at N-1 and C-7.

Authors:  T E Renau; J P Sanchez; J W Gage; J A Dever; M A Shapiro; S J Gracheck; J M Domagala
Journal:  J Med Chem       Date:  1996-02-02       Impact factor: 7.446

10.  Analysis of gyrA and grlA mutations in stepwise-selected ciprofloxacin-resistant mutants of Staphylococcus aureus.

Authors:  L Ferrero; B Cameron; J Crouzet
Journal:  Antimicrob Agents Chemother       Date:  1995-07       Impact factor: 5.191
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  82 in total

1.  Mutant prevention concentrations of fluoroquinolones for clinical isolates of Streptococcus pneumoniae.

Authors:  J M Blondeau; X Zhao; G Hansen; K Drlica
Journal:  Antimicrob Agents Chemother       Date:  2001-02       Impact factor: 5.191

2.  Selection of Streptococcus pneumoniae mutants having reduced susceptibility to moxifloxacin and levofloxacin.

Authors:  Xinying Li; Xilin Zhao; Karl Drlica
Journal:  Antimicrob Agents Chemother       Date:  2002-02       Impact factor: 5.191

3.  Use of mutator strains for characterization of novel antimicrobial agents.

Authors:  A J O'Neill; I Chopra
Journal:  Antimicrob Agents Chemother       Date:  2001-05       Impact factor: 5.191

4.  Concentration-dependent selection of small phenotypic differences in TEM beta-lactamase-mediated antibiotic resistance.

Authors:  M C Negri; M Lipsitch; J Blázquez; B R Levin; F Baquero
Journal:  Antimicrob Agents Chemother       Date:  2000-09       Impact factor: 5.191

5.  Effect of drug concentration on emergence of macrolide resistance in Mycobacterium avium.

Authors:  K A Nash
Journal:  Antimicrob Agents Chemother       Date:  2001-06       Impact factor: 5.191

6.  Selective advantage of resistant strains at trace levels of antibiotics: a simple and ultrasensitive color test for detection of antibiotics and genotoxic agents.

Authors:  Anne Liu; Amie Fong; Elinne Becket; Jessica Yuan; Cindy Tamae; Leah Medrano; Maria Maiz; Christine Wahba; Catherine Lee; Kim Lee; Katherine P Tran; Hanjing Yang; Robert M Hoffman; Anya Salih; Jeffrey H Miller
Journal:  Antimicrob Agents Chemother       Date:  2011-01-03       Impact factor: 5.191

7.  Fluoroquinolone Resistance in Salmonella and the Utility of Pefloxacin Disk Diffusion [corrected].

Authors:  Ferric C Fang
Journal:  J Clin Microbiol       Date:  2015-08-26       Impact factor: 5.948

8.  Mutant Prevention Concentration and Mutant Selection Window of Micafungin and Anidulafungin in Clinical Candida glabrata Isolates.

Authors:  Pilar Escribano; Jesús Guinea; María Ángeles Bordallo-Cardona; Laura Judith Marcos-Zambrano; Carlos Sánchez-Carrillo; Elia Gómez G de la Pedrosa; Rafael Cantón; Emilio Bouza
Journal:  Antimicrob Agents Chemother       Date:  2018-02-23       Impact factor: 5.191

9.  Mutant prevention concentrations of ABT-492, levofloxacin, moxifloxacin, and gatifloxacin against three common respiratory pathogens.

Authors:  Elizabeth D Hermsen; Laurie B Hovde; George N Konstantinides; John C Rotschafer
Journal:  Antimicrob Agents Chemother       Date:  2005-04       Impact factor: 5.191

10.  Low correlation between MIC and mutant prevention concentration.

Authors:  Karl Drlica; Xilin Zhao; Joseph M Blondeau; Christine Hesje
Journal:  Antimicrob Agents Chemother       Date:  2006-01       Impact factor: 5.191
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