Literature DB >> 10390147

Video microscopy of tumor metastasis: using the green fluorescent protein (GFP) gene as a cancer-cell-labeling system.

Z Kan1, T J Liu.   

Abstract

Video microscopy allows dynamic observation of cancer-cell activity in the microcirculation of live animals. However, observation of cancer invasion and metastasis in situ has never been successful because of the lack of a technique for labeling cancer cells. We report here our success with video microscopy of cancer-cell activity, detection of remote metastases and cancer cells endogenously generated using the green fluorescent protein (GFP) gene as a cell-labeling system in live animals. As a cell-labeling system, GFP is stable, efficient, and nontoxic, and it is passed on to subsequent generations of cells. This pilot experiment has demonstrated the feasibility of direct observation and documentation of tumor growth and tumor invasion as well as the metastatic activities of cancer cells in live animals.

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Year:  1999        PMID： 10390147     DOI： 10.1023/a:1026478105365

Source DB:  PubMed          Journal:  Clin Exp Metastasis        ISSN： 0262-0898            Impact factor:   5.150


  15 in total

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Authors:  L Weiss; U Nannmark; B R Johansson; U Bagge
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2.  Deformation-driven destruction of cancer cells in the microvasculature.

Authors:  L Weiss
Journal:  Clin Exp Metastasis       Date:  1993-09       Impact factor: 5.150

3.  New view of metastasis is spreading.

Authors:  D Holzman
Journal:  J Natl Cancer Inst       Date:  1996-10-02       Impact factor: 13.506

4.  Improved green fluorescence.

Authors:  R Heim; A B Cubitt; R Y Tsien
Journal:  Nature       Date:  1995-02-23       Impact factor: 49.962

5.  Cancer invasion and micrometastasis visualized in live tissue by green fluorescent protein expression.

Authors:  T Chishima; Y Miyagi; X Wang; H Yamaoka; H Shimada; A R Moossa; R M Hoffman
Journal:  Cancer Res       Date:  1997-05-15       Impact factor: 12.701

6.  Development and biologic properties of malignant cell sublines and clones of a spontaneously metastasizing rat mammary adenocarcinoma.

Authors:  A Neri; D Welch; T Kawaguchi; G L Nicolson
Journal:  J Natl Cancer Inst       Date:  1982-03       Impact factor: 13.506

Review 7.  Steps in tumor metastasis: new concepts from intravital videomicroscopy.

Authors:  A F Chambers; I C MacDonald; E E Schmidt; S Koop; V L Morris; R Khokha; A C Groom
Journal:  Cancer Metastasis Rev       Date:  1995-12       Impact factor: 9.264

8.  In vivo microscopy of hepatic metastases: dynamic observation of tumor cell invasion and interaction with Kupffer cells.

Authors:  Z Kan; K Ivancev; A Lunderquist; P A McCuskey; R S McCuskey; S Wallace
Journal:  Hepatology       Date:  1995-02       Impact factor: 17.425

9.  Early interactions of cancer cells with the microvasculature in mouse liver and muscle during hematogenous metastasis: videomicroscopic analysis.

Authors:  V L Morris; I C MacDonald; S Koop; E E Schmidt; A F Chambers; A C Groom
Journal:  Clin Exp Metastasis       Date:  1993-09       Impact factor: 5.150

10.  Retroviral transfer and expression of a humanized, red-shifted green fluorescent protein gene into human tumor cells.

Authors:  J P Levy; R R Muldoon; S Zolotukhin; C J Link
Journal:  Nat Biotechnol       Date:  1996-05       Impact factor: 54.908
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  7 in total

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Journal:  J Cancer Res Clin Oncol       Date:  2004-07       Impact factor: 4.553

2.  Liver anatomy: microcirculation of the liver.

Authors:  Zuxing Kan; David C Madoff
Journal:  Semin Intervent Radiol       Date:  2008-06       Impact factor: 1.513

Review 3.  Unravelling the complexity of metastasis - molecular understanding and targeted therapies.

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Journal:  Nat Rev Cancer       Date:  2011-09-23       Impact factor: 60.716

4.  A model of spontaneous lung metastases visualised in fresh host tissue by green fluorescent protein expression.

Authors:  S Paris; C Chauzy; N Martin-Vandelet; B Delpech; L Thiberville; J P Martin; M Diarra-Mehrpour
Journal:  Clin Exp Metastasis       Date:  1999       Impact factor: 5.150

Review 5.  Orthotopic metastatic mouse models for anticancer drug discovery and evaluation: a bridge to the clinic.

Authors:  R M Hoffman
Journal:  Invest New Drugs       Date:  1999       Impact factor: 3.850

Review 6.  Superresolution imaging using single-molecule localization.

Authors:  George Patterson; Michael Davidson; Suliana Manley; Jennifer Lippincott-Schwartz
Journal:  Annu Rev Phys Chem       Date:  2010       Impact factor: 12.703

7.  Reversal of diabetes in mice by intrahepatic injection of bone-derived GFP-murine mesenchymal stem cells infected with the recombinant retrovirus-carrying human insulin gene.

Authors:  Jian Xu; Yuhua Lu; Fei Ding; Xi Zhan; Mingyan Zhu; Zhiwei Wang
Journal:  World J Surg       Date:  2007-09       Impact factor: 3.352
  7 in total

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