[Involvement of the intracellular regulatory systems in the adaptive effect of short-term anoxia in vitro].

Moderate long-term activation of intracellular regulatory system (IRS) was found to be manifested as an increase in the bound calcium content and intensity of the phosphoinositide metabolism following a 30-minute re-oxygenation in the rat olfactory cortex perfused slices. The perfusate induced a similar activation in intact slices-recipients. Long-term anoxia induced a biphasic NMDA-dependent increase in intracellular free Ca2+ and pathogenic hyperactivity of the IRS. The pathogenic events could be prevented by preconditioning of the slices by either short-term anoxia (STA) or post-STA donor perfusate.