[The role of volume transmission of the adaptogenic signals in the formation of adaptive brain responses].

Different chemical factors of the volume transmission were found to be of importance for the latter process: peptides as possible transporting substances for adaptogenic signals as they were involved in mechanisms of the brain adaptogenic responses, particularly to tetanic stimulation of the neurones and hypoxic stress. Substances secreted by donor-slice cells following tetanic and anoxic stimulation were found to exert an obvious effect upon synaptic transmission inducing a long-term potentiation and protecting it against functional disturbances. Mechanisms of interaction between synaptic and volume transmission signals, are discussed.