| Literature DB >> 10386948 |
G W Muller1, R Chen, S Y Huang, L G Corral, L M Wong, R T Patterson, Y Chen, G Kaplan, D I Stirling.
Abstract
Thalidomide, (1), is a known inhibitor of TNF-alpha release in LPS stimulated human PBMC. Herein we describe the TNF-alpha inhibitory activity of amino substituted analogs of thalidomide (1) and its isoindolin-1-one analog, EM-12 (2). The 4-amino substituted analogs were found to be potent inhibitors of TNF-alpha release in LPS stimulated human PBMC.Entities:
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Year: 1999 PMID： 10386948 DOI： 10.1016/s0960-894x(99)00250-4
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823