Literature DB >> 10386943

Synthesis of 25-aminosterols, new antifungal agents.

P Beuchet1, M Dherbomez, L Elkiel, G Charles, Y Letourneux.   

Abstract

25-aminolanostenol 1 and 25-aminocholesterol 2 were hemisynthesized from natural sterols and tested in vitro against Candida albicans. The biological activity of compound 1 was rather weak, whereas 2 exhibited in vitro antifungal activity with MIC value of 4 microM.

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Year:  1999        PMID: 10386943     DOI: 10.1016/s0960-894x(99)00233-4

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  1 in total

1.  Syntheses and biological activity studies of novel sterol analogs from nitroso Diels-Alder reactions of ergosterol.

Authors:  Baiyuan Yang; Patricia A Miller; Ute Möllmann; Marvin J Miller
Journal:  Org Lett       Date:  2009-07-02       Impact factor: 6.005

  1 in total

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