| Literature DB >> 10386933 |
B E Maryanoff1, S O Nortey, J J McNally, P J Sanfilippo, D F McComsey, B Dubinsky, R P Shank, A B Reitz.
Abstract
A variety of pyrido[1,2-a]benzimidazoles (PBIs) modified on the A-ring were prepared and evaluated for affinity to the benzodiazepine binding site on the GABA-A receptor and in animal models predictive of anxiolytic activity in humans. A-ring benzo-fused derivative 7 exhibited potent activity, as did the 6- and 7-pyrido compounds 3 and 4.Entities:
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Year: 1999 PMID： 10386933 DOI： 10.1016/s0960-894x(99)00240-1
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823