Literature DB >> 10386926

Design of the first highly potent and selective aminopeptidase N (EC 3.4.11.2) inhibitor.

H Chen1, B P Roques, M C Fournié-Zaluski.   

Abstract

A series of phosphinic compounds mimicking the transition state of substrates hydrolysed by aminopeptidase N (EC 3.4.11.2) were synthesized. These new compounds have potent inhibitory activities with Ki values in the nanomolar range. These derivatives behave as the most potent APN inhibitors designed to date.

Entities:  

Mesh：

Substances：

Year:  1999        PMID： 10386926      PMCID： PMC7172755     

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  28 in total

1.  Bestatin, an inhibitor of aminopeptidase B, produced by actinomycetes.

Authors:  H Umezawa; T Aoyagi; H Suda; M Hamada; T Takeuchi
Journal:  J Antibiot (Tokyo)       Date:  1976-01       Impact factor: 2.649

2.  New kelatorphan-related inhibitors of enkephalin metabolism: improved antinociceptive properties.

Authors:  J Xie; J M Soleilhac; C Schmidt; J Peyroux; B P Roques; M C Fournié-Zaluski
Journal:  J Med Chem       Date:  1989-07       Impact factor: 7.446

3.  The aminopeptidase from hog intestinal brush border.

Authors:  S Maroux; D Louvard; J Baratti
Journal:  Biochim Biophys Acta       Date:  1973-09-15

4.  Production of actinonin, an inhibitor of aminopeptidase M, by actinomycetes.

Authors:  H Umezawa; T Aoyagi; T Tanaka; H Suda; A Okuyama; H Naganawa; M Hamada; T Takeuchi
Journal:  J Antibiot (Tokyo)       Date:  1985-11       Impact factor: 2.649

5.  Amastatin, an inhibitor of aminopeptidase A, produced by actinomycetes.

Authors:  T Aoyagi; H Tobe; F Kojima; M Hamada; T Takeuchi; H Umezawa
Journal:  J Antibiot (Tokyo)       Date:  1978-06       Impact factor: 2.649

6.  Inhibition of aminopeptidases by aminophosphonates.

Authors:  B Lejczak; P Kafarski; J Zygmunt
Journal:  Biochemistry       Date:  1989-04-18       Impact factor: 3.162

7.  Aminopeptidase N is a major receptor for the entero-pathogenic coronavirus TGEV.

Authors:  B Delmas; J Gelfi; R L'Haridon; L K Vogel; H Sjöström; O Norén; H Laude
Journal:  Nature       Date:  1992-06-04       Impact factor: 49.962

8.  Design of novel inhibitors of aminopeptidases. Synthesis of peptide-derived diamino thiols and sulfur replacement analogues of bestatin.

Authors:  E M Gordon; J D Godfrey; N G Delaney; M M Asaad; D Von Langen; D W Cushman
Journal:  J Med Chem       Date:  1988-11       Impact factor: 7.446

9.  Identification of glutamate residues essential for catalytic activity and zinc coordination in aminopeptidase A.

Authors:  G Vazeux; J Wang; P Corvol; C Llorens-Cortès
Journal:  J Biol Chem       Date:  1996-04-12       Impact factor: 5.157

10.  Role of aminopeptidase N (CD13) in tumor-cell invasion and extracellular matrix degradation.

Authors:  I Saiki; H Fujii; J Yoneda; F Abe; M Nakajima; T Tsuruo; I Azuma
Journal:  Int J Cancer       Date:  1993-04-22       Impact factor: 7.396
View more
  12 in total

1.  Serum protease activity in chronic kidney disease patients: The GANI_MED renal cohort.

Authors:  Carmen Wolke; Alexander Teumer; Karlhans Endlich; Nicole Endlich; Rainer Rettig; Sylvia Stracke; Beate Fiene; Simone Aymanns; Stephan B Felix; Anke Hannemann; Uwe Lendeckel
Journal:  Exp Biol Med (Maywood)       Date:  2016-12-30

2.  Aminopeptidase fingerprints, an integrated approach for identification of good substrates and optimal inhibitors.

Authors:  Marcin Drag; Matthew Bogyo; Jonathan A Ellman; Guy S Salvesen
Journal:  J Biol Chem       Date:  2009-11-30       Impact factor: 5.157

3.  Binding properties of a highly potent and selective iodinated aminopeptidase N inhibitor appropriate for radioautography.

Authors:  F Noble; N Luciani; S Da Nascimento; R Laï-Kuen; L Bischoff; H Chen; M C Fournié-Zaluski; B P Roques
Journal:  FEBS Lett       Date:  2000-02-04       Impact factor: 4.124

Review 4.  Metallo-aminopeptidase inhibitors.

Authors:  Artur Mucha; Marcin Drag; John P Dalton; Paweł Kafarski
Journal:  Biochimie       Date:  2010-05-10       Impact factor: 4.079

Review 5.  Aminopeptidase-N/CD13 (EC 3.4.11.2) inhibitors: chemistry, biological evaluations, and therapeutic prospects.

Authors:  Brigitte Bauvois; Daniel Dauzonne
Journal:  Med Res Rev       Date:  2006-01       Impact factor: 12.944

6.  Discovery of inhibitors of insulin-regulated aminopeptidase as cognitive enhancers.

Authors:  Hanna Andersson; Mathias Hallberg
Journal:  Int J Hypertens       Date:  2012-12-04       Impact factor: 2.420

7.  High glucose activates the alternative ACE2/Ang-(1-7)/Mas and APN/Ang IV/IRAP RAS axes in pancreatic β-cells.

Authors:  Carmen Härdtner; Caroline Mörke; Reinhard Walther; Carmen Wolke; Uwe Lendeckel
Journal:  Int J Mol Med       Date:  2013-08-14       Impact factor: 4.101

8.  Structure-guided, single-point modifications in the phosphinic dipeptide structure yield highly potent and selective inhibitors of neutral aminopeptidases.

Authors:  Stamatia Vassiliou; Ewelina Węglarz-Tomczak; Łukasz Berlicki; Małgorzata Pawełczak; Bogusław Nocek; Rory Mulligan; Andrzej Joachimiak; Artur Mucha
Journal:  J Med Chem       Date:  2014-09-22       Impact factor: 7.446

Review 9.  Synthesis and modifications of phosphinic dipeptide analogues.

Authors:  Artur Mucha
Journal:  Molecules       Date:  2012-11-15       Impact factor: 4.411

10.  Establishment of a screening protocol for identification of aminopeptidase N inhibitors.

Authors:  Miaomiao Niu; Fengzhen Wang; Fang Li; Yaru Dong; Yueqing Gu
Journal:  J Taiwan Inst Chem Eng       Date:  2014-12-31       Impact factor: 5.876
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.