| Literature DB >> 10386925 |
Q Dang1, B S Brown, P D van Poelje, T J Colby, M D Erion.
Abstract
A new prodrug approach for intracellular delivery of phosphonates was developed via the synthesis of 3-phthalidyl esters of 1-naphthalenemethylphosphonate. This approach is advantageous over the traditional acyloxymethyl phosphonate prodrugs, because these prodrugs do not generate formaldehyde and have improved plasma half-lives.Entities:
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Year: 1999 PMID： 10386925 DOI： 10.1016/s0960-894x(99)00239-5
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823