Literature DB >> 10386892

Panosialins, inhibitors of an alpha1,3-fucosyltransferase Fuc-TVII, suppress the expression of selectin ligands on U937 cells.

K Shinoda1, K Shitara, Y Yoshihara, A Kusano, Y Uosaki, S Ohta, N Hanai, I Takahashi.   

Abstract

Panosialins A and B were isolated as inhibitors of an alpha1,3-fucosyltransferase, Fuc-TVII, which is a key enzyme in the biosynthesis of selectin ligands, from culture broth of Streptomyces sp. Panosialins A and B inhibited the Fuc-TVII activity with IC50 values of 4.8 and 5.3 microg/ml, respectively. Panosialin A suppressed expression of selectin ligands on U937 cells, and inhibited the cell adhesion to immobilized E-selectin-immunoglobulin. Panosialins are the first reported Fuc-TVII inhibitors which can suppress the biosynthesis of selectin ligands and then inhibit selectin-mediated cell adhesion.

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Year:  1998        PMID： 10386892     DOI： 10.1023/a:1006953626578

Source DB:  PubMed          Journal:  Glycoconj J        ISSN： 0282-0080            Impact factor:   2.916


  15 in total

Review 1.  Selectins: interpreters of cell-specific carbohydrate information during inflammation.

Authors:  L A Lasky
Journal:  Science       Date:  1992-11-06       Impact factor: 47.728

Review 2.  Selectin ligands.

Authors:  A Varki
Journal:  Proc Natl Acad Sci U S A       Date:  1994-08-02       Impact factor: 11.205

3.  Expression of the alpha(1,3)fucosyltransferase Fuc-TVII in lymphoid aggregate high endothelial venules correlates with expression of L-selectin ligands.

Authors:  P L Smith; K M Gersten; B Petryniak; R J Kelly; C Rogers; Y Natsuka; J A Alford; E P Scheidegger; S Natsuka; J B Lowe
Journal:  J Biol Chem       Date:  1996-04-05       Impact factor: 5.157

4.  An enzyme inhibitor, panosialin, produced by Streptomyces. I. Biological activity, isolation and characterization of panosialin.

Authors:  T Aoyagi; M Yagisawa; M Kumagai; M Hamada; Y Okami
Journal:  J Antibiot (Tokyo)       Date:  1971-12       Impact factor: 2.649

5.  Enzymatic characterization of human alpha1,3-fucosyltransferase Fuc-TVII synthesized in a B cell lymphoma cell line.

Authors:  K Shinoda; Y Morishita; K Sasaki; Y Matsuda; I Takahashi; T Nishi
Journal:  J Biol Chem       Date:  1997-12-19       Impact factor: 5.157

6.  The alpha(1,3)fucosyltransferase Fuc-TVII controls leukocyte trafficking through an essential role in L-, E-, and P-selectin ligand biosynthesis.

Authors:  P Malý; A Thall; B Petryniak; C E Rogers; P L Smith; R M Marks; R J Kelly; K M Gersten; G Cheng; T L Saunders; S A Camper; R T Camphausen; F X Sullivan; Y Isogai; O Hindsgaul; U H von Andrian; J B Lowe
Journal:  Cell       Date:  1996-08-23       Impact factor: 41.582

7.  Expression cloning of a novel alpha 1,3-fucosyltransferase that is involved in biosynthesis of the sialyl Lewis x carbohydrate determinants in leukocytes.

Authors:  K Sasaki; K Kurata; K Funayama; M Nagata; E Watanabe; S Ohta; N Hanai; T Nishi
Journal:  J Biol Chem       Date:  1994-05-20       Impact factor: 5.157

Review 8.  The selectins: vascular adhesion molecules.

Authors:  T F Tedder; D A Steeber; A Chen; P Engel
Journal:  FASEB J       Date:  1995-07       Impact factor: 5.191

9.  Molecular cloning of a cDNA encoding a novel human leukocyte alpha-1,3-fucosyltransferase capable of synthesizing the sialyl Lewis x determinant.

Authors:  S Natsuka; K M Gersten; K Zenita; R Kannagi; J B Lowe
Journal:  J Biol Chem       Date:  1994-06-17       Impact factor: 5.157

10.  New glycosidases inhibitors, panosialins D and wD produced by Streptomyces sp. OH-5186.

Authors:  H Yamada; K Shiomi; Q Xu; T Nagai; M Shibata; I Oya; Y Takahashi; S Omura
Journal:  J Antibiot (Tokyo)       Date:  1995-03       Impact factor: 2.649
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  4 in total

Review 1.  Biological activity of phenolic lipids.

Authors:  Maria Stasiuk; A Kozubek
Journal:  Cell Mol Life Sci       Date:  2010-03       Impact factor: 9.261

Review 2.  Biosynthetic Machinery Involved in Aberrant Glycosylation: Promising Targets for Developing of Drugs Against Cancer.

Authors:  Andréia Vasconcelos-Dos-Santos; Isadora A Oliveira; Miguel Clodomiro Lucena; Natalia Rodrigues Mantuano; Stephen A Whelan; Wagner Barbosa Dias; Adriane Regina Todeschini
Journal:  Front Oncol       Date:  2015-06-25       Impact factor: 6.244

3.  Inhibitors of selectin functions in the treatment of inflammatory skin disorders.

Authors:  Michael P Schön
Journal:  Ther Clin Risk Manag       Date:  2005-09       Impact factor: 2.423

4.  Inhibition of fucosylation in human invasive ductal carcinoma reduces E-selectin ligand expression, cell proliferation, and ERK1/2 and p38 MAPK activation.

Authors:  Mylène A Carrascal; Mariana Silva; José S Ramalho; Cláudia Pen; Manuela Martins; Carlota Pascoal; Constança Amaral; Isabel Serrano; Maria José Oliveira; Robert Sackstein; Paula A Videira
Journal:  Mol Oncol       Date:  2018-03-30       Impact factor: 6.603
  4 in total

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