| Literature DB >> 10386598 |
M Kaneko1, T Kudo, H Iwasaki, Y Ikehara, S Nishihara, S Nakagawa, K Sasaki, T Shiina, H Inoko, N Saitou, H Narimatsu.
Abstract
The amino acid sequence of Fuc-TIX is very highly conserved between mouse and human. The number of non-synonymous nucleotide substitutions of the Fuc-TIX gene between human and mouse was strikingly low, and almost equivalent to that of the alpha-actin gene. This indicates that Fuc-TIX is under a strong selective pressure of preservation during evolution. The human Fuc-TIX (hFuc-TIX) showed a unique characteristics, i.e. hFuc-TIX was not activated by Mn2+ and Co2+, whereas hFuc-TIV and hFuc-TVI were activated by the cations. The hFuc-TIX transcripts were abundantly expressed in brain and stomach, and interestingly were detected in spleen and peripheral blood leukocytes.Entities:
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Year: 1999 PMID： 10386598 DOI： 10.1016/s0014-5793(99)00640-7
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124