BACKGROUND: To examine the magnetic resonance (MR) images of bipolar patients across a wide age range for the presence of hyperintense lesions compared to age- and gender-matched control subjects. METHODS: Consecutive admissions to a mood disorders unit over a 2-year period were evaluated retrospectively for the presence of bipolar disorder by DSM-III-R criteria and whether they received an MR scan. Bipolar patients (n = 70, mean age = 49.9 +/- 19.7 years) were age- and gender-matched to control subjects (n = 70, mean age = 53.2 +/- 18.1 years) and the MR scans were rated to assess for the presence of hyperintensites. RESULTS: Compared to control subjects, the bipolar patients demonstrated hyperintense lesions in the subependymal region, subcortical gray nuclei, and the deep white matter. CONCLUSIONS: Hyperintense lesions in bipolar patients are found in both the subcortical white matter and gray nuclei and may play an important role in the etiology of bipolar illness.
BACKGROUND: To examine the magnetic resonance (MR) images of bipolarpatients across a wide age range for the presence of hyperintense lesions compared to age- and gender-matched control subjects. METHODS: Consecutive admissions to a mood disorders unit over a 2-year period were evaluated retrospectively for the presence of bipolar disorder by DSM-III-R criteria and whether they received an MR scan. Bipolarpatients (n = 70, mean age = 49.9 +/- 19.7 years) were age- and gender-matched to control subjects (n = 70, mean age = 53.2 +/- 18.1 years) and the MR scans were rated to assess for the presence of hyperintensites. RESULTS: Compared to control subjects, the bipolarpatients demonstrated hyperintense lesions in the subependymal region, subcortical gray nuclei, and the deep white matter. CONCLUSIONS: Hyperintense lesions in bipolarpatients are found in both the subcortical white matter and gray nuclei and may play an important role in the etiology of bipolar illness.
Authors: Sarah K Tighe; Sarah A Reading; Paul Rivkin; Brian Caffo; Barbara Schweizer; Godfrey Pearlson; James B Potash; J Raymond Depaulo; Susan S Bassett Journal: Bipolar Disord Date: 2012-12 Impact factor: 6.744
Authors: Peter Kochunov; Joshua Chiappelli; Susan N Wright; Laura M Rowland; Beenish Patel; S Andrea Wijtenburg; Katie Nugent; Robert P McMahon; William T Carpenter; Florian Muellerklein; Hemalatha Sampath; L Elliot Hong Journal: Psychiatry Res Date: 2014-05-21 Impact factor: 3.222
Authors: Marcus V Zanetti; Maristela S Schaufelberger; Cláudio C de Castro; Paulo R Menezes; Márcia Scazufca; Philip K McGuire; Robin M Murray; Geraldo F Busatto Journal: Br J Psychiatry Date: 2008-07 Impact factor: 9.319