Literature DB >> 10383980

Molecular cloning and functional expression of alternative oxidase from Candida albicans.

W K Huh1, S O Kang.   

Abstract

The AOX1 gene, which encodes an alternative oxidase, was isolated from the genomic DNA library of Candida albicans. The gene encodes a polypeptide consisting of 379 amino acids with a calculated molecular mass of 43,975 Da. The aox1/aox1 mutant strain did not show cyanide-resistant respiration under normal conditions but could still induce cyanide-resistant respiration when treated with antimycin A. The measurement of respiratory activity and Western blot analysis suggested the presence of another AOX. When C. albicans AOX1 was expressed in alternative oxidase-deficient Saccharomyces cerevisiae, it could confer cyanide-resistant respiration on S. cerevisiae.

Entities:  

Mesh：

Substances：

Year:  1999        PMID： 10383980      PMCID： PMC93902     

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  31 in total

Review 1.  Cyanide-insensitive respiration. An alternative mitochondrial pathway.

Authors:  M F Henry; E D Nyns
Journal:  Subcell Biochem       Date:  1975-03

2.  Getting started with yeast.

Authors:  F Sherman
Journal:  Methods Enzymol       Date:  1991       Impact factor: 1.600

3.  Isolation and characterization of a cDNA clone encoding an alternative oxidase protein of Sauromatum guttatum (Schott).

Authors:  D M Rhoads; L McIntosh
Journal:  Proc Natl Acad Sci U S A       Date:  1991-03-15       Impact factor: 11.205

4.  Cleavage-site motifs in mitochondrial targeting peptides.

Authors:  Y Gavel; G von Heijne
Journal:  Protein Eng       Date:  1990-10

5.  Cloning and analysis of the alternative oxidase gene of Neurospora crassa.

Authors:  Q Li; R G Ritzel; L L McLean; L McIntosh; T Ko; H Bertrand; F E Nargang
Journal:  Genetics       Date:  1996-01       Impact factor: 4.562

6.  A simple method for displaying the hydropathic character of a protein.

Authors:  J Kyte; R F Doolittle
Journal:  J Mol Biol       Date:  1982-05-05       Impact factor: 5.469

7.  Respiration of bloodstream forms of the parasite Trypanosoma brucei brucei is dependent on a plant-like alternative oxidase.

Authors:  A B Clarkson; E J Bienen; G Pollakis; R W Grady
Journal:  J Biol Chem       Date:  1989-10-25       Impact factor: 5.157

8.  Partial purification of the cyanide-resistant alternative oxidase of skunk cabbage (Symplocarpus foetidus) mitochondria.

Authors:  D A Berthold; J N Siedow
Journal:  Plant Physiol       Date:  1993-01       Impact factor: 8.340

9.  The induction of cyanide-resistant respiration in Hansenula anomala.

Authors:  N Minagawa; A Yoshimoto
Journal:  J Biochem       Date:  1987-05       Impact factor: 3.387

10.  Mitochondrial electron transport regulation of nuclear gene expression. Studies with the alternative oxidase gene of tobacco.

Authors:  G C Vanlerberghe; L McIntosh
Journal:  Plant Physiol       Date:  1994-07       Impact factor: 8.340
View more
  14 in total

Review 1.  Classical and alternative components of the mitochondrial respiratory chain in pathogenic fungi as potential therapeutic targets.

Authors:  Vicente de Paulo Martins; Taisa Magnani Dinamarco; Carlos Curti; Sérgio Akira Uyemura
Journal:  J Bioenerg Biomembr       Date:  2011-02       Impact factor: 2.945

Review 2.  Mechanisms of resistance to oxidative and nitrosative stress: implications for fungal survival in mammalian hosts.

Authors:  Tricia A Missall; Jennifer K Lodge; Joan E McEwen
Journal:  Eukaryot Cell       Date:  2004-08

3.  Two zinc-cluster transcription factors control induction of alternative oxidase in Neurospora crassa.

Authors:  Michael S Chae; Cheryl E Nargang; Ian A Cleary; Colin C Lin; Andrea T Todd; Frank E Nargang
Journal:  Genetics       Date:  2007-12       Impact factor: 4.562

4.  Heterologous expression of the Crassostrea gigas (Pacific oyster) alternative oxidase in the yeast Saccharomyces cerevisiae.

Authors:  Aaron Robertson; Kyle Schaltz; Karina Neimanis; James F Staples; Allison E McDonald
Journal:  J Bioenerg Biomembr       Date:  2016-11-05       Impact factor: 2.945

5.  Characterization of the gene family encoding alternative oxidase from Candida albicans.

Authors:  W K Huh; S O Kang
Journal:  Biochem J       Date:  2001-06-01       Impact factor: 3.857

6.  Genome-wide expression profiling of the response to azole, polyene, echinocandin, and pyrimidine antifungal agents in Candida albicans.

Authors:  Teresa T Liu; Robin E B Lee; Katherine S Barker; Richard E Lee; Lai Wei; Ramin Homayouni; P David Rogers
Journal:  Antimicrob Agents Chemother       Date:  2005-06       Impact factor: 5.191

7.  Enzymatic dysfunction of mitochondrial complex I of the Candida albicans goa1 mutant is associated with increased reactive oxidants and cell death.

Authors:  Dongmei Li; Hui Chen; Abigail Florentino; Deepu Alex; Patricia Sikorski; William A Fonzi; Richard Calderone
Journal:  Eukaryot Cell       Date:  2011-03-11

8.  Transcriptional response of Candida albicans to nitric oxide and the role of the YHB1 gene in nitrosative stress and virulence.

Authors:  Bethann S Hromatka; Suzanne M Noble; Alexander D Johnson
Journal:  Mol Biol Cell       Date:  2005-07-19       Impact factor: 4.138

9.  Regulation of the alternative oxidase Aox1 gene in Chlamydomonas reinhardtii. Role of the nitrogen source on the expression of a reporter gene under the control of the Aox1 promoter.

Authors:  Denis Baurain; Monique Dinant; Nadine Coosemans; René F Matagne
Journal:  Plant Physiol       Date:  2003-03       Impact factor: 8.340

Review 10.  Gene Ontology and the annotation of pathogen genomes: the case of Candida albicans.

Authors:  Martha B Arnaud; Maria C Costanzo; Prachi Shah; Marek S Skrzypek; Gavin Sherlock
Journal:  Trends Microbiol       Date:  2009-07-03       Impact factor: 17.079
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.