Literature DB >> 10383943

Antigenic and immunogenic properties of totally synthetic peptide-based anti-fertility vaccines.

S Ghosh1, D C Jackson.   

Abstract

In this study we describe the results of experiments in which a variety of totally synthetic luteinizing hormone releasing hormone (LHRH) vaccines were assembled and examined for their abilities to elicit antibody responses and induce sterility in mice. It is shown that totally synthetic vaccines consisting of a 15 residue-defined T cell epitope and the 10 residue LHRH epitope not only induced high titers of antibody but also induced sterility. This effect did not appear to correlate with antibody titer, antibody isotype or comparative antibody affinity, but may be related to the length of time for which antibodies are present to exert their influence.

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Year:  1999        PMID： 10383943     DOI： 10.1093/intimm/11.7.1103

Source DB:  PubMed          Journal:  Int Immunol        ISSN： 0953-8178            Impact factor:   4.823


  7 in total

1.  A totally synthetic vaccine of generic structure that targets Toll-like receptor 2 on dendritic cells and promotes antibody or cytotoxic T cell responses.

Authors:  David C Jackson; Yuk Fai Lau; Thuy Le; Andreas Suhrbier; Georgia Deliyannis; Christina Cheers; Corey Smith; Weiguang Zeng; Lorena E Brown
Journal:  Proc Natl Acad Sci U S A       Date:  2004-10-15       Impact factor: 11.205

2.  Potential of lipid core peptide technology as a novel self-adjuvanting vaccine delivery system for multiple different synthetic peptide immunogens.

Authors:  Colleen Olive; Michael Batzloff; Aniko Horváth; Timothy Clair; Penny Yarwood; Istvan Toth; Michael F Good
Journal:  Infect Immun       Date:  2003-05       Impact factor: 3.441

3.  Identification of canine helper T-cell epitopes from the fusion protein of canine distemper virus.

Authors:  S Ghosh; J Walker; D C Jackson
Journal:  Immunology       Date:  2001-09       Impact factor: 7.397

4.  Humoral hyporesponsiveness to a conjugate contraceptive vaccine and its bypass by diverse carriers using permissible adjuvant.

Authors:  A Mandokhot; R Pal; S Nagpal; V S Chauhan; S Ahlawat; O Singh
Journal:  Clin Exp Immunol       Date:  2000-10       Impact factor: 4.330

5.  The hinge region fragment of immunoglobulin G improves immunogenicity of recombinant gonadotrophin-releasing hormone conjugated to the T-helper epitope in designing peptide vaccines.

Authors:  Jinshu Xu; Jie Wu; Xuejun Wang; Yin Zhang; Wenjia Li; Zheng Zhu; Dongya Zhu; Zhuoyi Hu; Rouel S Roque; Jingjing Liu
Journal:  Immunology       Date:  2008-11-24       Impact factor: 7.397

6.  Current status of multiple antigen-presenting peptide vaccine systems: Application of organic and inorganic nanoparticles.

Authors:  Yoshio Fujita; Hiroaki Taguchi
Journal:  Chem Cent J       Date:  2011-08-23       Impact factor: 4.215

7.  Synthetic B-Cell Epitopes Eliciting Cross-Neutralizing Antibodies: Strategies for Future Dengue Vaccine.

Authors:  Babu Ramanathan; Chit Laa Poh; Kristin Kirk; William John Hannan McBride; John Aaskov; Lara Grollo
Journal:  PLoS One       Date:  2016-05-25       Impact factor: 3.240
  7 in total

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