Literature DB >> 10383555

Transaminase elevation on placebo during phase I trials: prevalence and significance.

P Rosenzweig1, N Miget, S Brohier.   

Abstract

AIMS: To evaluate the prevalence of transaminase elevation on placebo during Phase I trials.
METHODS: Retrospective review of pooled transaminase data collected on placebo during 13 Phase I trials in 93 healthy volunteers hospitalized for 14 days, with determination of the prevalence of abnormally high values.
RESULTS: 20.4% of the 93 subjects showed at least one ALT value above the upper limit of the normal range (ULN), and 7.5% had at least one value twice ULN.
CONCLUSIONS: Laboratory safety results of Phase I trials should be interpreted with caution, in the light of data on placebo, to avoid premature discontinuation of the development of safe drugs wrongly believed to be hepatotoxic.

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Year:  1999        PMID: 10383555      PMCID: PMC2014876          DOI: 10.1046/j.1365-2125.1999.00952.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN: 0306-5251            Impact factor:   4.335


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