Literature DB >> 10380736

Cell proliferation in spiral ligament of mouse cochlea damaged by dihydrostreptomycin sulfate.

H Yamashita1, H Shimogori, K Sugahara, M Takahashi.   

Abstract

Cell proliferation of the spiral ligament in the normal and drug-induced damaged mice cochleae was investigated using the mitotic tracer bromodcoxyuridine (BrdU). Only a few nuclei labelled by BrdU were seen in the spiral ligament of the control mouse. However, many BrdU labelled nuclei in the spiral ligament in the cochlea damaged by dihydrostreptomycin sulfate were found. The expression of fibroblast growth factor receptor and connexin 43 was detected in the spiral ligament where BrdU labelled cells were found. These results suggest that cell proliferation in the spiral ligament may occur after the drug-induced damage, and this process is probably related to the recovery of cochlear function.

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Year:  1999        PMID： 10380736     DOI： 10.1080/00016489950181323

Source DB:  PubMed          Journal:  Acta Otolaryngol        ISSN： 0001-6489            Impact factor:   1.494


  9 in total

1.  Chronic reduction of endocochlear potential reduces auditory nerve activity: further confirmation of an animal model of metabolic presbyacusis.

Authors:  Hainan Lang; Vinu Jyothi; Nancy M Smythe; Judy R Dubno; Bradley A Schulte; Richard A Schmiedt
Journal:  J Assoc Res Otolaryngol       Date:  2010-04-06

2.  Sox2 up-regulation and glial cell proliferation following degeneration of spiral ganglion neurons in the adult mouse inner ear.

Authors:  Hainan Lang; Manna Li; Lauren A Kilpatrick; Juhong Zhu; Devadoss J Samuvel; Edward L Krug; John C Goddard
Journal:  J Assoc Res Otolaryngol       Date:  2011-04

3.  Heptanol application to the mouse round window: a model for studying cochlear lateral wall regeneration.

Authors:  Shawn M Stevens; Yazhi Xing; Christopher T Hensley; Juhong Zhu; Judy R Dubno; Hainan Lang
Journal:  Otolaryngol Head Neck Surg       Date:  2014-01-16       Impact factor: 3.497

4.  Effects of chronic furosemide treatment and age on cell division in the adult gerbil inner ear.

Authors:  H Lang; B A Schulte; R A Schmiedt
Journal:  J Assoc Res Otolaryngol       Date:  2003-06

5.  Adeno-associated virus-mediated gene delivery into the scala media of the normal and deafened adult mouse ear.

Authors:  L A Kilpatrick; Q Li; J Yang; J C Goddard; D M Fekete; H Lang
Journal:  Gene Ther       Date:  2011-01-06       Impact factor: 5.250

6.  Characterization of slow-cycling cells in the mouse cochlear lateral wall.

Authors:  Yang Li; Kotaro Watanabe; Masato Fujioka; Kaoru Ogawa
Journal:  PLoS One       Date:  2017-06-20       Impact factor: 3.240

7.  CDK2 inhibitors as candidate therapeutics for cisplatin- and noise-induced hearing loss.

Authors:  Tal Teitz; Jie Fang; Asli N Goktug; Justine D Bonga; Shiyong Diao; Robert A Hazlitt; Luigi Iconaru; Marie Morfouace; Duane Currier; Yinmei Zhou; Robyn A Umans; Michael R Taylor; Cheng Cheng; Jaeki Min; Burgess Freeman; Junmin Peng; Martine F Roussel; Richard Kriwacki; R Kiplin Guy; Taosheng Chen; Jian Zuo
Journal:  J Exp Med       Date:  2018-03-07       Impact factor: 14.307

Review 8.  Translational and interdisciplinary insights into presbyacusis: A multidimensional disease.

Authors:  Mark A Eckert; Kelly C Harris; Hainan Lang; Morag A Lewis; Richard A Schmiedt; Bradley A Schulte; Karen P Steel; Kenneth I Vaden; Judy R Dubno
Journal:  Hear Res       Date:  2020-10-31       Impact factor: 3.208

Review 9.  Spontaneous recovery of cochlear fibrocytes after severe degeneration caused by acute energy failure.

Authors:  Kunio Mizutari
Journal:  Front Pharmacol       Date:  2014-08-26       Impact factor: 5.810
  9 in total

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