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Literature DB >> 10377378

Augmenting beta receptors in the heart: short-term gains offset by long-term pains?

L E Limbird¹, D E Vaughan.

Abstract

Entities: Disease

Mesh：

Substances：

Year: 1999 PMID： 10377378 PMCID： PMC33583 DOI： 10.1073/pnas.96.13.7125

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

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15 in total

1. Restoration of beta-adrenergic signaling in failing cardiac ventricular myocytes via adenoviral-mediated gene transfer.

Authors: S A Akhter; C A Skaer; A P Kypson; P H McDonald; K C Peppel; D D Glower; R J Lefkowitz; W J Koch
Journal: Proc Natl Acad Sci U S A Date: 1997-10-28 Impact factor: 11.205

2. Clinical effects of beta-adrenergic blockade in chronic heart failure: a meta-analysis of double-blind, placebo-controlled, randomized trials.

Authors: P Lechat; M Packer; S Chalon; M Cucherat; T Arab; J P Boissel
Journal: Circulation Date: 1998-09-22 Impact factor: 29.690

Review 3. Turning off the signal: desensitization of beta-adrenergic receptor function.

Authors: W P Hausdorff; M G Caron; R J Lefkowitz
Journal: FASEB J Date: 1990-08 Impact factor: 5.191

4. Multiple pathways of rapid beta 2-adrenergic receptor desensitization. Delineation with specific inhibitors.

Authors: M J Lohse; J L Benovic; M G Caron; R J Lefkowitz
Journal: J Biol Chem Date: 1990-02-25 Impact factor: 5.157

5. Identification of a specific site required for rapid heterologous desensitization of the beta-adrenergic receptor by cAMP-dependent protein kinase.

Authors: R B Clark; J Friedman; R A Dixon; C D Strader
Journal: Mol Pharmacol Date: 1989-09 Impact factor: 4.436

Augmenting beta receptors in the heart: short-term gains offset by long-term pains?

1. Restoration of beta-adrenergic signaling in failing cardiac ventricular myocytes via adenoviral-mediated gene transfer.

2. Clinical effects of beta-adrenergic blockade in chronic heart failure: a meta-analysis of double-blind, placebo-controlled, randomized trials.

Review 3. Turning off the signal: desensitization of beta-adrenergic receptor function.

4. Multiple pathways of rapid beta 2-adrenergic receptor desensitization. Delineation with specific inhibitors.

5. Identification of a specific site required for rapid heterologous desensitization of the beta-adrenergic receptor by cAMP-dependent protein kinase.

6. Transgenic animal models: new avenues in cardiovascular physiology.

7. Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor.

8. Decreased catecholamine sensitivity and beta-adrenergic-receptor density in failing human hearts.

9. Myocardial beta-adrenergic receptor function during the development of pacing-induced heart failure.

10. Altered expression of beta-adrenergic receptor kinase and beta 1-adrenergic receptors in the failing human heart.

1. Trans-Golgi Network (TGN) as a regulatory node for β1-adrenergic receptor (β1AR) down-modulation and recycling.

2. Endocytosis machinery is required for beta1-adrenergic receptor-induced hypertrophy in neonatal rat cardiac myocytes.

3. Cardioprotection specific for the G protein Gi2 in chronic adrenergic signaling through beta 2-adrenoceptors.