Literature DB >> 10377156

Legionella pneumophila contains a type II general secretion pathway required for growth in amoebae as well as for secretion of the Msp protease.

L M Hales1, H A Shuman.   

Abstract

We report the identification of a set of Legionella pneumophila genes that encode products with homology to proteins of the type II general secretion pathway of gram-negative bacteria. A strain containing a deletion-substitution mutation of two of these genes was unable to secrete the Msp protease. This strain was unable to multiply within the free-living amoeba Acanthamoeba castellanii yet was able to kill HL-60-derived macrophages. Because Msp is not required for growth in amoebae, other proteins which are important for growth in amoebae are likely secreted by this pathway.

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Year:  1999        PMID： 10377156      PMCID： PMC116561     

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  50 in total

1.  Conjugative transfer by the virulence system of Legionella pneumophila.

Authors:  J P Vogel; H L Andrews; S K Wong; R R Isberg
Journal:  Science       Date:  1998-02-06       Impact factor: 47.728

Review 2.  Intracellular multiplication of Legionella pneumophila: human pathogen or accidental tourist?

Authors:  H A Shuman; M Purcell; G Segal; L Hales; L A Wiater
Journal:  Curr Top Microbiol Immunol       Date:  1998       Impact factor: 4.291

3.  The secretion apparatus of Pseudomonas aeruginosa: identification of a fifth pseudopilin, XcpX (GspK family).

Authors:  S Bleves; R Voulhoux; G Michel; A Lazdunski; J Tommassen; A Filloux
Journal:  Mol Microbiol       Date:  1998-01       Impact factor: 3.501

4.  General secretion pathway (eps) genes required for toxin secretion and outer membrane biogenesis in Vibrio cholerae.

Authors:  M Sandkvist; L O Michel; L P Hough; V M Morales; M Bagdasarian; M Koomey; V J DiRita; M Bagdasarian
Journal:  J Bacteriol       Date:  1997-11       Impact factor: 3.490

5.  Current views on the relationships between amoebae, legionellae and man.

Authors:  T J Rowbotham
Journal:  Isr J Med Sci       Date:  1986-09

6.  Separation of Legionella pneumophila proteases and purification of a protease which produces lesions like those of Legionnaires' disease in guinea pig lung.

Authors:  J W Conlan; A Baskerville; L A Ashworth
Journal:  J Gen Microbiol       Date:  1986-06

7.  Purification and characterization of an extracellular protease of Legionella pneumophila.

Authors:  L A Dreyfus; B H Iglewski
Journal:  Infect Immun       Date:  1986-03       Impact factor: 3.441

8.  Isolation of Legionella pneumophila from clinical specimens via amoebae, and the interaction of those and other isolates with amoebae.

Authors:  T J Rowbotham
Journal:  J Clin Pathol       Date:  1983-09       Impact factor: 3.411

9.  Cloning and expression in Escherichia coli of the Klebsiella pneumoniae genes for production, surface localization and secretion of the lipoprotein pullulanase.

Authors:  C d'Enfert; A Ryter; A P Pugsley
Journal:  EMBO J       Date:  1987-11       Impact factor: 11.598

10.  Characterization of avirulent mutant Legionella pneumophila that survive but do not multiply within human monocytes.

Authors:  M A Horwitz
Journal:  J Exp Med       Date:  1987-11-01       Impact factor: 14.307
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  54 in total

1.  Legionella pneumophila major acid phosphatase and its role in intracellular infection.

Authors:  V Aragon; S Kurtz; N P Cianciotto
Journal:  Infect Immun       Date:  2001-01       Impact factor: 3.441

2.  The DotA protein from Legionella pneumophila is secreted by a novel process that requires the Dot/Icm transporter.

Authors:  H Nagai; C R Roy
Journal:  EMBO J       Date:  2001-11-01       Impact factor: 11.598

3.  icmT is essential for pore formation-mediated egress of Legionella pneumophila from mammalian and protozoan cells.

Authors:  Maelle Molmeret; O A Terry Alli; Steven Zink; Antje Flieger; Nicholas P Cianciotto; Yousef Abu Kwaik
Journal:  Infect Immun       Date:  2002-01       Impact factor: 3.441

Review 4.  Type II secretion and pathogenesis.

Authors:  M Sandkvist
Journal:  Infect Immun       Date:  2001-06       Impact factor: 3.441

5.  Purification and characterization of a UDP-glucosyltransferase produced by Legionella pneumophila.

Authors:  Iouri Belyi; Michel R Popoff; Nicholas P Cianciotto
Journal:  Infect Immun       Date:  2003-01       Impact factor: 3.441

Review 6.  Molecular pathogenesis of infections caused by Legionella pneumophila.

Authors:  Hayley J Newton; Desmond K Y Ang; Ian R van Driel; Elizabeth L Hartland
Journal:  Clin Microbiol Rev       Date:  2010-04       Impact factor: 26.132

7.  The Legionella pneumophila tatB gene facilitates secretion of phospholipase C, growth under iron-limiting conditions, and intracellular infection.

Authors:  Ombeline Rossier; Nicholas P Cianciotto
Journal:  Infect Immun       Date:  2005-04       Impact factor: 3.441

8.  Role for RpoS but not RelA of Legionella pneumophila in modulation of phagosome biogenesis and adaptation to the phagosomal microenvironment.

Authors:  Alaeddin Abu-Zant; Rexford Asare; James E Graham; Yousef Abu Kwaik
Journal:  Infect Immun       Date:  2006-05       Impact factor: 3.441

9.  Legionella pneumophila type II protein secretion promotes virulence in the A/J mouse model of Legionnaires' disease pneumonia.

Authors:  Ombeline Rossier; Shawn R Starkenburg; Nicholas P Cianciotto
Journal:  Infect Immun       Date:  2004-01       Impact factor: 3.441

10.  Temporal and spatial trigger of post-exponential virulence-associated regulatory cascades by Legionella pneumophila after bacterial escape into the host cell cytosol.

Authors:  Maëlle Molmeret; Snake Jones; Marina Santic; Fabien Habyarimana; Maria Teresa Garcia Esteban; Yousef Abu Kwaik
Journal:  Environ Microbiol       Date:  2009-12-02       Impact factor: 5.491
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