Literature DB >> 10376680

Endocytosis and intracellular transport of ricin: recent discoveries.

K Sandvig1, B van Deurs.   

Abstract

The plant toxin ricin has proven valuable as a membrane marker in studies of endocytosis as well as studies of different intracellular transport steps. The toxin, which consists of two polypeptide chains, binds by one chain (the B-chain) to both glycolipids and glycoproteins with terminal galactose at the cell surface. The other chain (the A-chain) enters the cytosol and inhibits protein synthesis enzymatically. After binding the toxin is endocytosed by different mechanisms, and it is transported via endosomes to the Golgi apparatus and the endoplasmic reticulum before translocation of the A-chain to the cytosol. The different transport steps have been analyzed by studying trafficking of ricin as well as modified ricin molecules.

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Year:  1999        PMID： 10376680     DOI： 10.1016/s0014-5793(99)00529-3

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  26 in total

Review 1.  Entry of ricin and Shiga toxin into cells: molecular mechanisms and medical perspectives.

Authors:  K Sandvig; B van Deurs
Journal:  EMBO J       Date:  2000-11-15       Impact factor: 11.598

2.  Endosome to Golgi transport of ricin is independent of clathrin and of the Rab9- and Rab11-GTPases.

Authors:  T G Iversen; G Skretting; A Llorente; P Nicoziani; B van Deurs; K Sandvig
Journal:  Mol Biol Cell       Date:  2001-07       Impact factor: 4.138

3.  Plasma membrane cholesterol modulates cellular vacuolation induced by the Helicobacter pylori vacuolating cytotoxin.

Authors:  Hetal K Patel; David C Willhite; Rakhi M Patel; Dan Ye; Christopher L Williams; Eric M Torres; Kent B Marty; Robert A MacDonald; Steven R Blanke
Journal:  Infect Immun       Date:  2002-08       Impact factor: 3.441

4.  Shiga toxin is transported from the endoplasmic reticulum following interaction with the luminal chaperone HEDJ/ERdj3.

Authors:  Min Yu; David B Haslam
Journal:  Infect Immun       Date:  2005-04       Impact factor: 3.441

5.  Endosome to Golgi transport of ricin is regulated by cholesterol.

Authors:  S Grimmer; T G Iversen; B van Deurs; K Sandvig
Journal:  Mol Biol Cell       Date:  2000-12       Impact factor: 4.138

6.  Syntaxin 16 and syntaxin 5 are required for efficient retrograde transport of several exogenous and endogenous cargo proteins.

Authors:  Mohamed Amessou; Alexandre Fradagrada; Thomas Falguières; J Michael Lord; Daniel C Smith; Lynne M Roberts; Christophe Lamaze; Ludger Johannes
Journal:  J Cell Sci       Date:  2007-03-27       Impact factor: 5.285

7.  Lipolytic activity of ricin from Ricinus sanguineus and Ricinus communis on neutral lipids.

Authors:  S Lombard; M E Helmy; G Piéroni
Journal:  Biochem J       Date:  2001-09-15       Impact factor: 3.857

8.  Sterol carrier protein-2 expression alters sphingolipid metabolism in transfected mouse L-cell fibroblasts.

Authors:  Daniel G Milis; Messiah K Moore; Barbara P Atshaves; Friedhelm Schroeder; John R Jefferson
Journal:  Mol Cell Biochem       Date:  2006-02       Impact factor: 3.396

9.  Purification, characterization and cloning of a ricin B-like lectin from mushroom Clitocybe nebularis with antiproliferative activity against human leukemic T cells.

Authors:  Jure Pohleven; Natasa Obermajer; Jerica Sabotic; Sabina Anzlovar; Kristina Sepcić; Janko Kos; Bogdan Kralj; Borut Strukelj; Joze Brzin
Journal:  Biochim Biophys Acta       Date:  2008-12-06

10.  Enzyme replacement for GM1-gangliosidosis: Uptake, lysosomal activation, and cellular disease correction using a novel β-galactosidase:RTB lectin fusion.

Authors:  Jose Condori; Walter Acosta; Jorge Ayala; Varun Katta; Ashley Flory; Reid Martin; Jonathan Radin; Carole L Cramer; David N Radin
Journal:  Mol Genet Metab       Date:  2015-12-08       Impact factor: 4.797
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