Literature DB >> 10375707

In vivo microdialysis measures of extracellular serotonin in the rat hippocampus during sleep-wakefulness.

S P Park1, F Lopez-Rodriguez, C L Wilson, N Maidment, Y Matsumoto, J Engel.   

Abstract

We investigated extracellular 5-hydroxytryptamine (5-HT) levels in rat hippocampus during different stages of the sleep-waking cycle using in vivo microdialysis. The extracellular 5-HT level was highest in active waking (AW) and, when compared to AW, 5-HT level was progressively lower in quiet waking (QW; 78%), quiet sleep (QS; 50%) and REM (which we termed active sleep (AS); 40%). Functional implications of AS related-decreased 5-HT in the hippocampus are discussed. Copyright 1999 Elsevier Science B.V.

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Year:  1999        PMID: 10375707     DOI: 10.1016/s0006-8993(99)01511-5

Source DB:  PubMed          Journal:  Brain Res        ISSN: 0006-8993            Impact factor:   3.252


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