Literature DB >> 10375679

Enhancement of prepulse inhibition after blockade of GABA activity within the superior colliculus.

M Fendt1.   

Abstract

The present study examined the effects of local microinjections of the GABA chloride channel blocker Picrotoxin into the superior colliculus (SC) on prepulse inhibition (PPI) of the acoustic startle response (ASR) in rats. PPI is a useful model for the investigation of the neuronal basis of sensorimotor gating which is deficient in some psychiatric disorders, such as schizophrenia. Blockade of GABA activity within the SC by Picrotoxin injections (leading to a moderate stimulation of the SC) significantly enhanced PPI without affecting the ASR baseline amplitude or the spontaneous motor activity. Based on these results we discuss the role of the SC in a hypothetical neuronal circuit mediating PPI of the ASR. Copyright 1999 Elsevier Science B.V.

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Year:  1999        PMID： 10375679     DOI： 10.1016/s0006-8993(99)01525-5

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  14 in total

Review 1.  Inhibitory deficit in schizophrenia is not necessarily a GABAergic deficit.

Authors:  Diogo R Lara
Journal:  Cell Mol Neurobiol       Date:  2002-06       Impact factor: 5.046

2.  The Role of Cholinergic Midbrain Neurons in Startle and Prepulse Inhibition.

Authors:  Erin Azzopardi; Andrea G Louttit; Cleusa DeOliveira; Steven R Laviolette; Susanne Schmid
Journal:  J Neurosci       Date:  2018-08-31       Impact factor: 6.167

3.  Sex differences in anxiety, sensorimotor gating and expression of the alpha4 subunit of the GABAA receptor in the amygdala after progesterone withdrawal.

Authors:  M Gulinello; R Orman; S S Smith
Journal:  Eur J Neurosci       Date:  2003-02       Impact factor: 3.386

Review 4.  Schizophrenia: a review of neuropharmacology.

Authors:  J Lyne; B D Kelly; W T O'Connor
Journal:  Ir J Med Sci       Date:  2004 Jul-Sep       Impact factor: 1.568

5.  Role of nicotinic receptors in the lateral habenula in the attenuation of amphetamine-induced prepulse inhibition deficits of the acoustic startle response in rats.

Authors:  José A Larrauri; Dennis A Burke; Brandon J Hall; Edward D Levin
Journal:  Psychopharmacology (Berl)       Date:  2015-04-28       Impact factor: 4.530

6.  Prepulse inhibition in fragile X syndrome: feasibility, reliability, and implications for treatment.

Authors:  David Hessl; Elizabeth Berry-Kravis; Lisa Cordeiro; Jennifer Yuhas; Edward M Ornitz; Aaron Campbell; Elizabeth Chruscinski; Crystal Hervey; James M Long; Randi J Hagerman
Journal:  Am J Med Genet B Neuropsychiatr Genet       Date:  2009-06-05       Impact factor: 3.568

7.  The amygdala modulates prepulse inhibition of the auditory startle reflex through excitatory inputs to the caudal pontine reticular nucleus.

Authors:  Jose Carlos Cano; Wanyun Huang; Karine Fénelon
Journal:  BMC Biol       Date:  2021-06-03       Impact factor: 7.431

8.  Brief report: Sensorimotor gating in idiopathic autism and autism associated with fragile X syndrome.

Authors:  Jennifer Yuhas; Lisa Cordeiro; Flora Tassone; Elizabeth Ballinger; Andrea Schneider; James M Long; Edward M Ornitz; David Hessl
Journal:  J Autism Dev Disord       Date:  2011-02

9.  Prenatal VPA Exposure and Changes in Sensory Processing by the Superior Colliculus.

Authors:  Georgia Dendrinos; Marie Hemelt; Asaf Keller
Journal:  Front Integr Neurosci       Date:  2011-10-20

10.  Whole-body prepulse inhibition protocol to test sensorymotor gating mechanisms in monkeys.

Authors:  Patricia G Saletti; Rafael S Maior; Etsuro Hori; Ricardo Miyasaka de Almeida; Hisao Nishijo; Carlos Tomaz
Journal:  PLoS One       Date:  2014-08-21       Impact factor: 3.240
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