| Literature DB >> 10375618 |
W J Freebern1, E G Niles, P T LoVerde.
Abstract
A cDNA encoding a second full-length member of the Schistosoma mansoni RXR family (SmRXR-2) was identified. The nucleotide sequence of SmRXR-2 translates into a protein of 784 amino acids with a pI of 7.63 and an approximate mass of 78kDa making it the largest reported RXR to date. Phylogenetic tree analysis provides evidence that SmRXR-2 is the most ancient full-length RXR identified. SmRXR-2 exhibits unique sequence features compared with other RXRs. RT-PCR results demonstrate that the SmRXR-2 gene is constitutively expressed and thus must play multiple roles throughout schistosome development in the vertebrate host.Mesh：
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Year: 1999 PMID： 10375618 DOI： 10.1016/s0378-1119(99)00161-4
Source DB: PubMed Journal: Gene ISSN： 0378-1119 Impact factor: 3.688